Annexin V Antibody (E-10): sc-271015

Annexin V Antibody (E-10) is a mouse monoclonal IgG2b kappa light chain antibody designed to detect Annexin V, also known as ANXA5, Lipocortin V, Endonexin II, Calphobindin I, or Placental Anticoagulant Protein 4, across various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-Annexin V antibody (E-10) is raised against a peptide mapping at the N-terminus of human Annexin V, ensuring precise targeting of unique structural regions. Annexin V is a crucial member of the annexin family of calcium-binding proteins, characterized by a conserved core domain that forms a propeller-like structure essential for binding phospholipids in a calcium-dependent manner, and a distinct N-terminal domain that provides binding specificity and facilitates interactions with other cellular proteins. The structural integrity of Annexin V is vital for regulating membrane dynamics, apoptotic cell recognition by binding to phosphatidylserine, and involvement in processes such as ion flux, endocytosis, exocytosis, and cellular adhesion. Annexin V′s ability to form ion channels and regulate protein kinase C (PKC) activity underscores its importance in cellular signaling pathways and membrane organization. Annexin V monoclonal antibody (E-10) exhibits broad species reactivity, effectively recognizing Annexin V from mouse, rat, human, and additional species including porcine, making this antibody a versatile tool for comparative studies across different models. Available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates, Annexin V (E-10) antibody provides flexible options to suit diverse experimental needs. Anti-Annexin V antibody (E-10) ensures reliable detection and quantification of Annexin V, facilitating advanced research into structural functions and involvement in pathological conditions such as apoptosis, inflammation, and cancer.

The preferred Annexin V antibody is Annexin V Antibody (H-3): sc-74438.