Annexin V Antibody (A-2): sc-393669

Annexin V Antibody (A-2) is a mouse monoclonal IgG2a kappa light chain antibody engineered to detect Annexin V, also known as Lipocortin V or Annexin 5, across multiple applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-Annexin V antibody (A-2) targets a precise epitope within the C-terminus of human Annexin V, specifically amino acids 298-319, ensuring selective binding and high specificity. Annexin V is a pivotal member of the annexin family of calcium-binding proteins, playing a crucial role in the regulation of membrane dynamics and the recognition of apoptotic cells by binding to phosphatidylserine in a calcium-dependent manner. This function is essential for processes such as apoptosis, inflammation, and cellular adhesion, making Annexin V a valuable biomarker in studies related to cell death and various disease mechanisms. The structural integrity of Annexin V, characterized by its conserved core domain and unique C-terminal region, facilitates its interaction with cellular membranes and other proteins, thereby influencing key signaling pathways and maintaining cellular homeostasis. Annexin V monoclonal antibody (A-2) demonstrates broad species reactivity, effectively recognizing Annexin V from mouse, rat, and human origins, which makes it a versatile tool for comparative studies across different model organisms. Available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates, Annexin V (A-2) antibody offers flexibility to meet diverse experimental requirements. Anti-Annexin V antibody (A-2) provides high affinity and specificity for reliable detection and quantification of Annexin V, enabling researchers to explore its functional roles and involvement in pathological conditions such as cancer, cardiovascular diseases, and autoimmune disorders.

The preferred Annexin V antibody is Annexin V Antibody (H-3): sc-74438.