Annexin III Antibody (G-1): sc-390700

Annexin III Antibody (G-1) is a mouse monoclonal IgG1 kappa light chain antibody that detects Annexin III of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-Annexin III antibody (G-1) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Annexin III, also known as ANXA3, Lipocortin III, or PAP-III, belongs to the annexin family of calcium-binding proteins, playing crucial roles in cellular processes. Annexin III primarily resides in the cytoplasm and moves to the cell membrane in response to calcium ions, which enables cellular signaling and membrane dynamics. Annexin III′s ability to bind phospholipids in a calcium-dependent manner facilitates participation in processes such as apoptosis, cell proliferation, and membrane repair. Annexin III′s interaction with other proteins, including phospholipase A2, highlights a role in modulating inflammatory responses and cellular adhesion. These diverse functions underscore Annexin III′s importance in maintaining cellular homeostasis and potential as a therapeutic target in various diseases.

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Annexin III Antibody (G-1) References:

1. Ca(2+) and membrane binding to annexin 3 modulate the structure and dynamics of its N terminus and domain III.  |  Sopkova, J., et al. 2002. Protein Sci. 11: 1613-25. PMID: 12070314
2. Overexpression of ANXA3 is an independent prognostic indicator in gastric cancer and its depletion suppresses cell proliferation and tumor growth.  |  Wang, K. and Li, J. 2016. Oncotarget. 7: 86972-86984. PMID: 27894078
3. miR-18b attenuates cerebral ischemia/reperfusion injury through regulation of ANXA3 and PI3K/Akt signaling pathway.  |  Min, XL., et al. 2020. Brain Res Bull. 161: 55-64. PMID: 32380186
4. microRNA-382 suppresses the progression of pancreatic cancer through the PI3K/Akt signaling pathway by inhibition of Anxa3.  |  Wan, X., et al. 2020. Am J Physiol Gastrointest Liver Physiol. 319: G309-G322. PMID: 32463333
5. The H2BG53D oncohistone directly upregulates ANXA3 transcription and enhances cell migration in pancreatic ductal adenocarcinoma.  |  Wan, YCE., et al. 2020. Signal Transduct Target Ther. 5: 106. PMID: 32606294
6. PRMT1-Mediated Arginine Methylation Promotes Corneal Epithelial Wound Healing via Epigenetic Regulation of ANXA3.  |  Cao, Q., et al. 2025. Invest Ophthalmol Vis Sci. 66: 22. PMID: 39786757
7. Discovery of a Novel 1,4-Benzodiazepine Derivative as a Highly Selective ANXA3 Degrader for the Treatment of Triple-Negative Breast Cancer.  |  Liu, K., et al. 2025. J Med Chem. 68: 5358-5381. PMID: 40013713
8. FOXD1-activated ANXA3 facilitates cisplatin resistance of lung cancer cells via promoting ANXA4 expression.  |  Tan, Q., et al. 2025. Naunyn Schmiedebergs Arch Pharmacol.. PMID: 40095055
9. Prader-Willi syndrome gene expression profiling of obese and non-obese patients reveals transcriptional changes in CLEC4D and ANXA3.  |  Yoon, JY., et al. 2025. J Pediatr Endocrinol Metab.. PMID: 40105403
10. Annexin 3 is associated with cytoplasmic granules in neutrophils and monocytes and translocates to the plasma membrane in activated cells.  |  Le Cabec, V. and Maridonneau-Parini, I. 1994. Biochem J. 303 (Pt 2): 481-7. PMID: 7526843

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Annexin III Antibody (G-1) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-Annexin III Antibody (G-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Annexin III Antibody (G-1) Specifications

Alternate Product Name: Annexin III

Product Clone Name: G-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-50

Epitope Target: Annexin III

Epitope Species: human

Product Reactivity/Detection: Annexin III

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for Annexin III Antibody (G-1): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred Annexin III antibody is Annexin III Antibody (E-11): sc-390502.