Annexin I Antibody (39): sc-130305

Annexin I Antibody (39) is a mouse monoclonal IgG1 kappa light chain antibody designed to detect Annexin I, also known as ANXA1 and Lipocortin I. Anti-Annexin I antibody (39) is raised against recombinant Annexin I of human origin, ensuring precise recognition in applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Annexin I is a pivotal member of the annexin family of calcium-binding proteins, characterized by a conserved core domain that facilitates calcium-dependent phospholipid binding and a unique N-terminal region that confers binding specificity. Structurally, Annexin I interacts with various proteins, including formyl peptide receptors (FPRs) and cytosolic phospholipase A2 (cPLA2), which are critical for its role in mediating anti-inflammatory responses and regulating eicosanoid production. These interactions are essential for Annexin I′s function in inhibiting cPLA2, thereby reducing the synthesis of pro-inflammatory mediators and modulating the cellular response to glucocorticoids. Additionally, Annexin I interacts with proteins involved in cellular trafficking processes such as endocytosis and exocytosis, highlighting its importance in maintaining cellular homeostasis and facilitating communication between cells. The ability of Annexin I to bind and regulate these interacting proteins underscores its significance in various physiological and pathological contexts, including inflammation, cancer, and tissue repair. By utilizing Annexin I (39) monoclonal antibody, researchers can effectively study these interactions and elucidate the complex mechanisms by which Annexin I influences cellular processes. Annexin I (39) monoclonal antibody is an indispensable tool for scientists aiming to advance their understanding of Annexin I′s role in health and disease, making this reagent a valuable addition to any research laboratory focused on cellular biology and inflammatory pathways.

The preferred Annexin I antibody is Annexin I Antibody (EH17a): sc-12740.