Ankyrin G Antibody (3G8): sc-70359

Ankyrin G Antibody (3G8) is a mouse monoclonal IgG1 antibody that detects Ankyrin G in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Ankyrin G is a crucial member of the Ankyrin family of proteins, which play a vital role in linking integral membrane proteins to the cytoskeleton, thereby maintaining cellular structure and function. Anti-Ankyrin G antibody (3G8) recognizes a protein predominantly localized to the nodes of Ranvier and axon initial segments in neurons, where Ankyrin G is essential for the proper functioning of sodium channels, facilitating the rapid propagation of action potentials. Ankyrin G′s location in these critical sites ensures efficient neuronal signaling and communication. Additionally, Ankyrin G exhibits tissue-specific alternative mRNA processing, resulting in various isoforms that are predominantly expressed in nervous tissue, while smaller isoforms are found in other organs such as the lung, kidney, spleen, liver, and heart. The diverse expression patterns and functional roles of Ankyrin G underscore its importance in both neuronal health and overall cellular integrity, making Ankyrin G monoclonal antibody (3G8) an invaluable tool for researchers studying these processes.

The preferred Ankyrin G antibody is Ankyrin G Antibody (463): sc-12719.