Ankyrin B Antibody (3G7): sc-70358

Ankyrin B Antibody (3G7) is a mouse monoclonal IgG1 antibody that detects Ankyrin B in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Ankyrin B is a crucial member of the Ankyrin family of proteins, which play a vital role in linking integral membrane proteins to the cytoskeleton, thereby maintaining cellular structure and function. Anti-Ankyrin B antibody (3G7) recognizes a protein predominantly located in the plasma membrane of neurons and glial cells throughout the brain, where Ankyrin B is essential for normal neuronal functions. Ankyrin B at the plasma membrane facilitates the assembly of key ion transporters and receptors, including the sodium/calcium exchanger and sodium/potassium ATPase, which are critical for maintaining ionic balance and signaling in cardiomyocytes. Additionally, Ankyrin B undergoes alternative splicing, resulting in various isoforms that can have distinct functional roles, further emphasizing its importance in cellular dynamics. Ankyrin B monoclonal antibody (3G7) serves as an invaluable tool for researchers studying the intricate mechanisms of neuronal function and cytoskeletal organization in various biological contexts.

The preferred Ankyrin B antibody is Ankyrin B Antibody (2.20): sc-12718.