ANKMY1 Antibody (H-10): sc-514974
- ANKMY1 Antibody (H-10) is a mouse monoclonal IgG1 κ ANKMY1 antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 444-466 within an internal region of ANKMY1 of human origin
- ANKMY1 Antibody (H-10) is recommended for detection of ANKMY1 of human origin by WB, IP, IF and ELISA
- Anti-ANKMY1 Antibody (H-10) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for ANKMY1 Antibody (H-10). This work is in progress.
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ANKMY1 Antibody (H-10) is a mouse monoclonal IgG1 kappa light chain antibody that detects ANKMY1 of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-ANKMY1 antibody (H-10) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. ANKMY1, also known as ZMYND13 or TSAL1, is a 941 amino acid protein characterized by the presence of seven ankyrin repeats, three MORN repeats, and one MYND-type zinc finger. The ankyrin repeats are crucial for mediating protein-protein interactions, while the MORN repeats, first identified in junctophilins, suggest a potential role in linking the plasma membrane to the endoplasmic reticulum or sarcoplasmic reticulum, which is vital for maintaining cellular integrity and signaling. The MYND domain, with its unique arrangement of cysteine and histidine residues, may facilitate further interactions with other proteins, underscoring ANKMY1′s importance in cellular processes. Three isoforms of ANKMY1 arise from alternative splicing, adding complexity to its functional roles in various biological contexts. Mutations in ankyrin genes, including ANKMY1, have been linked to severe genetic disorders, such as fatal cardiac arrhythmias and hereditary spherocytosis, highlighting ANKMY1′s significance in health and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
ANKMY1 Antibody (H-10) References:
- Ankyrins, multifunctional proteins involved in many cellular pathways. | Hryniewicz-Jankowska, A., et al. 2002. Folia Histochem Cytobiol. 40: 239-49. PMID: 12219834
- Molecular evolution of ankyrin: gain of function in vertebrates by acquisition of an obscurin/titin-binding-related domain. | Hopitzan, AA., et al. 2006. Mol Biol Evol. 23: 46-55. PMID: 16135777
- Molecular evolution of the ankyrin gene family. | Cai, X. and Zhang, Y. 2006. Mol Biol Evol. 23: 550-8. PMID: 16280541
- MORN motifs in plant PIPKs are involved in the regulation of subcellular localization and phospholipid binding. | Ma, H., et al. 2006. Cell Res. 16: 466-78. PMID: 16699542
- Drosophila retinophilin contains MORN repeats and is conserved in humans. | Mecklenburg, KL. 2007. Mol Genet Genomics. 277: 481-9. PMID: 17285308
- Ankyrin and synapsin: spectrin-binding proteins associated with brain membranes. | Bennett, V., et al. 1985. J Cell Biochem. 29: 157-69. PMID: 2933418
- The fibronectin type III domain as a scaffold for novel binding proteins. | Koide, A., et al. 1998. J Mol Biol. 284: 1141-51. PMID: 9837732
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ANKMY1 Antibody (H-10) | sc-514974 | 200 µg/ml | $322.00 | |||
ANKMY1 Antibody (H-10) AC | sc-514974 AC | 500 µg/ml, 25% agarose | $424.00 | |||
ANKMY1 Antibody (H-10) HRP | sc-514974 HRP | 200 µg/ml | $322.00 | |||
ANKMY1 Antibody (H-10) FITC | sc-514974 FITC | 200 µg/ml | $336.00 | |||
ANKMY1 Antibody (H-10) PE | sc-514974 PE | 200 µg/ml | $349.00 | |||
ANKMY1 Antibody (H-10) Alexa Fluor® 488 | sc-514974 AF488 | 200 µg/ml | $364.00 | |||
ANKMY1 Antibody (H-10) Alexa Fluor® 546 | sc-514974 AF546 | 200 µg/ml | $364.00 | |||
ANKMY1 Antibody (H-10) Alexa Fluor® 594 | sc-514974 AF594 | 200 µg/ml | $364.00 | |||
ANKMY1 Antibody (H-10) Alexa Fluor® 647 | sc-514974 AF647 | 200 µg/ml | $364.00 | |||
ANKMY1 Antibody (H-10) Alexa Fluor® 680 | sc-514974 AF680 | 200 µg/ml | $364.00 | |||
ANKMY1 Antibody (H-10) Alexa Fluor® 790 | sc-514974 AF790 | 200 µg/ml | $364.00 | |||
ANKMY1 (H-10) Neutralizing Peptide | sc-514974 P | 100 µg/0.5 ml | $69.00 |