Angptl1 Antibody (A-5): sc-365146

Angptl1 Antibody (A-5) is a mouse monoclonal IgG2a antibody that detects Angptl1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Angptl1, also known as angiopoietin-like 1, angioarrestin, ARP1, ANGPT3, or previously angiopoietin 3 (ANG3), is a member of the angiopoietin-like family and is predominantly expressed in adult tissues, including the adrenal gland, thyroid, placenta, and small intestine. Angptl1 exists as a disulfide-linked dimer and shares significant sequence identity with Ang-1 and Angptl2, highlighting evolutionary conservation. Angptl1 features a coiled-coil domain at its N-terminus, potential glycosylation sites, and a fibrinogen-like domain at its C-terminus, which are crucial for structural integrity and functional interactions. Angptl1 plays a vital role in regulating angiogenesis by inhibiting endothelial cell proliferation, migration, tube formation, and adhesion, which is essential for maintaining vascular homeostasis. Anti-Angptl1 antibody (A-5) enables researchers to investigate antiangiogenic properties, particularly significant since Angptl1 expression is often down-regulated in various tumor tissues, suggesting a tumor suppressor role by limiting blood vessel formation. Angptl1 monoclonal antibody (A-5) serves as an invaluable tool for investigating angiogenesis mechanisms and potential therapeutic applications in cancer and other diseases.

The preferred Angptl1 antibody is Angptl1 Antibody (A-3): sc-271841.