Angiopoietin 1/Ang-1/ANGPT1 Antibody (C5): sc-517593

Ang-1 Antibody (C5) is a mouse monoclonal IgG antibody that detects Ang-1 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Anti-Ang-1 antibody (C5) is available as non-conjugated format, providing researchers with a reliable tool for studying this critical protein. Angiopoietin-1 (Ang-1) plays a vital role in angiogenesis, which is the formation of new blood vessels, and is essential for proper endothelial cell development and function. Ang-1 is primarily secreted and acts as a ligand for the Tie-2 receptor, which is crucial for vascular stability and integrity. Ang-1′s interaction with Tie-2 promotes endothelial cell survival and inhibits apoptosis, making Ang-1 a key player in maintaining vascular homeostasis. Additionally, Ang-1 has a potential fibrinogen-like domain at its carboxy terminus and coiled-coil regions at the amino terminus, which may influence interactions and functional properties. Understanding the mechanisms of Ang-1 and signaling pathways is important for developing therapeutic strategies for diseases characterized by abnormal angiogenesis, such as cancer and diabetic retinopathy. Furthermore, angiopoietin-2 (Ang-2) acts as a natural antagonist to Ang-1, highlighting the delicate balance of angiogenic factors in vascular dynamics regulation.

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Angiopoietin 1/Ang-1/ANGPT1 Antibody (C5) References:

1. A novel endothelial cell surface receptor tyrosine kinase with extracellular epidermal growth factor homology domains.  |  Partanen, J., et al. 1992. Mol Cell Biol. 12: 1698-707. PMID: 1312667
2. tek, a novel tyrosine kinase gene located on mouse chromosome 4, is expressed in endothelial cells and their presumptive precursors.  |  Dumont, DJ., et al. 1992. Oncogene. 7: 1471-80. PMID: 1630810
3. Co-Application of C16 and Ang-1 Improves the Effects of Levodopa in Parkinson Disease Treatment.  |  Fu, XX., et al. 2022. J Inflamm Res. 15: 3797-3814. PMID: 35836722
4. Prognostic value of tumour tissue ANG-1 expression and Ang-1 concentration in patients with non-small-cell lung cancer.  |  Zalewska-Ziob, M., et al. 2022. Pol J Pathol. 73: 6-13. PMID: 35848475
5. Value of Serum miR-34a and Ang-1 in Severity Evaluation and Prognosis of Neonatal Respiratory Distress Syndrome.  |  Li, Q., et al. 2022. Emerg Med Int. 2022: 5480026. PMID: 36186528
6. Ang-1, Ang-2, and Tie2 are diagnostic biomarkers for Henoch-Schönlein purpura and pediatric-onset systemic lupus erythematous.  |  Jia, L., et al. 2024. Open Life Sci. 19: 20220812. PMID: 38465338
7. Ang-1 and VEGF: central regulators of angiogenesis.  |  Zhao, Y., et al. 2024. Mol Cell Biochem.. PMID: 38652215
8. Ang-1 promotes tumorigenesis and mediates the anti-cancer effects of Artesunate on Choroidal melanoma via the regulation of Akt/mTOR signaling pathway.  |  Yao, N., et al. 2024. Cytokine. 184: 156771. PMID: 39340959
9. The endothelial-specific receptor tyrosine kinase, tek, is a member of a new subfamily of receptors.  |  Dumont, DJ., et al. 1993. Oncogene. 8: 1293-301. PMID: 8386827
10. Tie-1 and tie-2 define another class of putative receptor tyrosine kinase genes expressed in early embryonic vascular system.  |  Sato, TN., et al. 1993. Proc Natl Acad Sci U S A. 90: 9355-8. PMID: 8415706
11. Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning.  |  Davis, S., et al. 1996. Cell. 87: 1161-9. PMID: 8980223
12. Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis.  |  Maisonpierre, PC., et al. 1997. Science. 277: 55-60. PMID: 9204896

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Angiopoietin 1/Ang-1/ANGPT1 Antibody (C5) has 5 citations in a variety of scientific publications.

Primary antibodies like Anti-Angiopoietin 1/Ang-1/ANGPT1 Antibody (C5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Angiopoietin 1/Ang-1/ANGPT1 Antibody (C5) Specifications

Alternate Product Name: ANG1

Product Clone Name: C5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG

Amino Acids:

Epitope Target: Ang-1

Epitope Species: human

Product Reactivity/Detection: angiopoietin-1

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P)

Vialing Information: Each vial contains 100 µg IgG in 1.0 ml of PBS with < 0.1% sodium azide, 0.1% gelatin and 5% glycerol

Research Citations: 5 citations in various scientific publications

Available Conjugates/Forms for Angiopoietin 1/Ang-1/ANGPT1 Antibody (C5): N/A

The preferred Angiopoietin 1/Ang-1/ANGPT1 antibody is Angiopoietin 1/Ang-1/ANGPT1 Antibody (D-6): sc-518157.