AMPKγ2 Antibody (F-2): sc-398804

AMPKγ2 Antibody (F-2) is a mouse monoclonal IgG1 kappa light chain antibody that detects AMPK gamma 2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-AMPKγ2 antibody (F-2) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. AMPKγ2 is a crucial component of the AMP-activated protein kinase (AMPK) complex, which plays a vital role in cellular energy homeostasis. Located primarily in the cytoplasm, AMPK is activated in response to low energy states, such as high AMP and low ATP levels, which is essential for maintaining cellular function during metabolic stress. AMPK activation leads to phosphorylation of key regulatory enzymes involved in lipid and cholesterol metabolism, such as hydroxy-methylglutaryl-CoA reductase and acetyl-CoA carboxylase, thereby promoting energy conservation and restoring ATP levels. Unique N-terminal domains of AMPKγ2 and AMPKγ3 facilitate AMP binding, further enhancing the complex′s ability to sense and respond to cellular energy changes. AMPKγ2 serves as both a critical player in metabolic regulation and a potential target for therapeutic interventions in metabolic disorders.

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AMPKγ2 Antibody (F-2) References:

1. Characterization of AMP-activated protein kinase gamma-subunit isoforms and their role in AMP binding.  |  Cheung, PC., et al. 2000. Biochem J. 346 Pt 3: 659-69. PMID: 10698692
2. Glycogen storage disease as a unifying mechanism of disease in the PRKAG2 cardiac syndrome.  |  Gollob, MH. 2003. Biochem Soc Trans. 31: 228-31. PMID: 12546691
3. Targeting Antisense lncRNA PRKAG2-AS1, as a Therapeutic Target, Suppresses Malignant Behaviors of Hepatocellular Carcinoma Cells.  |  Ou, Y., et al. 2021. Front Med (Lausanne). 8: 649279. PMID: 33928106
4. Long-Term Cardiac Complications of PRKAG2 Syndrome.  |  Magalhães, LP., et al. 2022. Arq Bras Cardiol. 118: 106-109. PMID: 35195217
5. Controversial molecular functions of CBS versus non-CBS domain variants of PRKAG2 in arrhythmia and cardiomyopathy: A case report and literature review.  |  Gong, X., et al. 2022. Mol Genet Genomic Med. 10: e1962. PMID: 35588295
6. Identification of the pathogenic effects of missense variants causing PRKAG2 cardiomyopathy.  |  Komurcu-Bayrak, E., et al. 2022. Arch Biochem Biophys. 727: 109340. PMID: 35787834
7. Intrafamilial Phenotypical Variability Linked to PRKAG2 Mutation-Family Case Report and Review of the Literature.  |  Marcu, AS., et al. 2022. Life (Basel). 12: PMID: 36556501
8. Abnormal expression of PRKAG2-AS results in dysfunction of cardiomyocytes through regulating PRKAG2 transcription by interacting with PPARG.  |  Song, XW., et al. 2023. Clin Epigenetics. 15: 178. PMID: 37932845
9. Mammalian AMP-activated protein kinase subfamily.  |  Stapleton, D., et al. 1996. J Biol Chem. 271: 611-4. PMID: 8557660
10. The AMP-activated protein kinase--fuel gauge of the mammalian cell?  |  Hardie, DG. and Carling, D. 1997. Eur J Biochem. 246: 259-73. PMID: 9208914
11. AMP-activated protein kinase isoenzyme family: subunit structure and chromosomal location.  |  Stapleton, D., et al. 1997. FEBS Lett. 409: 452-6. PMID: 9224708
12. Identification of a novel AMP-activated protein kinase beta subunit isoform that is highly expressed in skeletal muscle.  |  Thornton, C., et al. 1998. J Biol Chem. 273: 12443-50. PMID: 9575201

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-AMPKγ2 Antibody (F-2) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-AMPKγ2 Antibody (F-2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

AMPKγ2 Antibody (F-2) Specifications

Alternate Product Name: AMPKγ2

Product Clone Name: F-2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 36-65

Epitope Target: AMPKγ2

Epitope Species: human

Product Reactivity/Detection: AMPKγ2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for AMPKγ2 Antibody (F-2): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin