AMPK Inhibitors

BML-275 is a selective activator of AMPK that engages in unique molecular interactions, enhancing the enzyme's activity through a distinct binding mechanism. This compound stabilizes the active conformation of AMPK, promoting its phosphorylation of downstream targets. By influencing metabolic signaling pathways, BML-275 modulates energy balance and lipid metabolism. Its specific structural features enable targeted engagement with AMPK, driving cellular responses to energy fluctuations.

Dorsomorphin dihydrochloride is a potent inhibitor of AMPK, characterized by its ability to selectively disrupt the enzyme's regulatory functions. It interacts with the AMPK complex, altering its conformation and inhibiting downstream signaling pathways. This compound exhibits unique kinetics, affecting the phosphorylation state of various substrates. Its distinct structural attributes facilitate targeted inhibition, influencing cellular energy homeostasis and metabolic processes.

STO-609 acetate salt is a selective inhibitor of AMPK, known for its unique ability to modulate the enzyme's activity through specific binding interactions. It alters the conformational dynamics of the AMPK complex, impacting its phosphorylation mechanisms. The compound's distinct chemical structure allows for precise engagement with regulatory sites, influencing metabolic signaling pathways. Its kinetic profile reveals a nuanced interaction with cellular energy sensors, affecting overall metabolic regulation.

Doxorubicin hydrochloride exhibits unique interactions with cellular components, particularly through its intercalation into DNA, which disrupts replication and transcription processes. This compound also influences redox signaling pathways, enhancing oxidative stress responses. Its distinct planar structure facilitates π-π stacking with nucleobases, while its ability to form stable complexes with topoisomerase II alters enzyme kinetics, leading to significant effects on cellular proliferation and apoptosis.

Fasudil, Monohydrochloride Salt, acts as a potent modulator of AMPK activity, influencing energy homeostasis at the cellular level. Its unique ability to enhance phosphorylation of AMPK promotes metabolic shifts, particularly in glucose and lipid metabolism. The compound engages in specific interactions with upstream kinases, altering signaling cascades that regulate cellular energy balance. Additionally, its solubility characteristics facilitate effective cellular uptake, impacting downstream metabolic pathways.

GSK 690693 is a potent AMPK activator that uniquely interacts with the enzyme's allosteric sites, promoting a conformational shift that enhances its catalytic activity. This compound exhibits rapid kinetics, facilitating efficient phosphorylation of downstream targets involved in metabolic regulation. Its distinctive structural features allow for selective engagement with specific protein domains, influencing cellular energy homeostasis and metabolic signaling pathways. The compound's stability in aqueous environments further supports its role in modulating cellular responses to energy stress.

γ-D-Glutamylaminomethylsulfonic acid serves as a distinctive regulator of AMPK, engaging in intricate molecular interactions that modulate energy metabolism. Its structure allows for selective binding to key regulatory sites, influencing the activation of AMPK through unique conformational changes. This compound also exhibits notable reaction kinetics, enhancing the phosphorylation process and thereby affecting metabolic pathways related to nutrient sensing and energy expenditure. Its physicochemical properties contribute to its stability and reactivity in biological systems, facilitating targeted cellular responses.