AMPKβ2 Antibody (F-8): sc-376897
- AMPKβ2 Antibody (F-8) is a mouse monoclonal IgA κ provided at 200 µg/ml
- raised against amino acids 1-75 mapping at the N-terminus of AMPKβ2 of human origin
- recommended for detection of AMPKβ2 of mouse, rat and human origin by WB, IP, IF and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for AMPKβ2 Antibody (F-8). This work is in progress.
AMPKβ2 Antibody (F-8) is a mouse monoclonal IgA antibody that detects AMPKβ2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). AMPKβ2 is a crucial regulatory subunit of the AMP-activated protein kinase (AMPK) complex, which plays a vital role in cellular energy homeostasis. AMPKβ2 is primarily located in the cytoplasm and is essential for the proper functioning of AMPK, as AMPKβ2 helps to stabilize the complex and facilitate activation in response to cellular energy stress. AMPKβ2′s presence in the cytoplasm allows for rapid signaling in response to fluctuations in cellular energy levels, enabling the cell to adapt metabolic pathways accordingly. By interacting with the catalytic α subunit and the γ subunit, AMPKβ2 ensures that the AMPK complex can effectively respond to changes in AMP and ATP concentrations, thus regulating key metabolic processes such as glucose uptake and fatty acid oxidation. AMPKβ2′s ability to modulate these pathways is critical for maintaining energy balance and preventing metabolic disorders, making AMPKβ2 an important target for research in areas such as obesity, diabetes, and cancer.
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AMPKβ2 Antibody (F-8) References:
- Role of the alpha2-isoform of AMP-activated protein kinase in the metabolic response of the heart to no-flow ischemia. | Zarrinpashneh, E., et al. 2006. Am J Physiol Heart Circ Physiol. 291: H2875-83. PMID: 16877552
- Control of glycogen synthase through ADIPOR1-AMPK pathway in renal distal tubules of normal and diabetic rats. | Cammisotto, PG., et al. 2008. Am J Physiol Renal Physiol. 294: F881-9. PMID: 18256313
- AMPKβ subunits: more than just a scaffold in the formation of AMPK complex. | Sanz, P., et al. 2013. FEBS J. 280: 3723-33. PMID: 23721051
- AMP-activated protein kinase complexes containing the β2 regulatory subunit are up-regulated during and contribute to adipogenesis. | Katwan, OJ., et al. 2019. Biochem J. 476: 1725-1740. PMID: 31189568
- Niclosamide activates the AMP-activated protein kinase complex containing the β2 subunit independently of AMP. | Suzuki, T., et al. 2020. Biochem Biophys Res Commun. 533: 758-763. PMID: 32993962
- Effect of Quercetin on Lipids Metabolism Through Modulating the Gut Microbial and AMPK/PPAR Signaling Pathway in Broilers. | Wang, M., et al. 2021. Front Cell Dev Biol. 9: 616219. PMID: 33634119
- TNF-induced necroptosis initiates early autophagy events via RIPK3-dependent AMPK activation, but inhibits late autophagy. | Wu, W., et al. 2021. Autophagy. 17: 3992-4009. PMID: 33779513
- Skeletal muscle cell-specific differences in type 2 diabetes. | Frankenberg, NT., et al. 2022. Cell Mol Life Sci. 79: 256. PMID: 35460430
- AMP-activated protein kinase β1 or β2 deletion enhances colon cancer cell growth and tumorigenesis. | Shi, F., et al. 2022. Acta Biochim Biophys Sin (Shanghai). 54: 1140-1147. PMID: 35880569
- Suppression of neuronal AMPKβ2 isoform impairs recognition memory and synaptic plasticity. | Swift, NA., et al. 2024. Neurobiol Dis. 201: 106664. PMID: 39278510
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
AMPKβ2 Antibody (F-8) | sc-376897 | 200 µg/ml | $322.00 |