AMPKβ1 Antibody (142A2R): sc-517606
- AMPKβ1 Antibody (142A2R) is a mouse monoclonal IgG1 κ provided at 100 µg/ml
- raised against recombinant AMPKβ1 of human origin
- recommended for detection of AMPKβ1 of mouse, rat and human origin by WB
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for AMPKβ1 Antibody (142A2R). This work is in progress.
AMPKβ1 Antibody (142A2R) is a mouse monoclonal IgG1 antibody that detects AMPKβ1 in mouse, rat, and human samples through western blotting (WB). AMPKβ1 is a crucial regulatory subunit of the AMP-activated protein kinase (AMPK) complex, which plays a vital role in cellular energy homeostasis. AMPKβ1 is primarily located in the cytoplasm and is essential for the proper functioning of AMPK, as AMPKβ1 helps to stabilize the complex and facilitate activation in response to cellular energy stress. AMPKβ1′s presence in the cytoplasm allows for rapid signaling in response to fluctuations in ATP levels, enabling the cell to adapt metabolic pathways accordingly. By promoting the phosphorylation of key enzymes involved in energy metabolism, such as acetyl-CoA carboxylase and hydroxy-methylglutaryl-CoA reductase, AMPKβ1 helps to maintain energy balance and prevent cellular damage during periods of low energy availability. AMPKβ1 consists of 271 amino acids and interacts with the α and γ subunits to form the heterotrimeric AMPK complex, which is critical for function. Anti-AMPKβ1 antibody (142A2R) is an invaluable tool for researchers studying metabolic regulation and energy homeostasis in various biological contexts.
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AMPKβ1 Antibody (142A2R) References:
- The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways. | Feng, Z., et al. 2007. Cancer Res. 67: 3043-53. PMID: 17409411
- A-769662 activates AMPK beta1-containing complexes but induces glucose uptake through a PI3-kinase-dependent pathway in mouse skeletal muscle. | Treebak, JT., et al. 2009. Am J Physiol Cell Physiol. 297: C1041-52. PMID: 19657063
- Angiotensin II regulates activation of Bim via Rb/E2F1 during apoptosis: involvement of interaction between AMPKβ1/2 and Cdk4. | Kim, YC. and Day, RM. 2012. Am J Physiol Lung Cell Mol Physiol. 303: L228-38. PMID: 22659879
- Salsalate (Salicylate) Uncouples Mitochondria, Improves Glucose Homeostasis, and Reduces Liver Lipids Independent of AMPK-β1. | Smith, BK., et al. 2016. Diabetes. 65: 3352-3361. PMID: 27554471
- AMPK β1 activation suppresses antipsychotic-induced hyperglycemia in mice. | Shamshoum, H., et al. 2019. FASEB J. 33: 14010-14021. PMID: 31581839
- AMPKβ1 and AMPKβ2 define an isoform-specific gene signature in human pluripotent stem cells, differentially mediating cardiac lineage specification. | Ziegler, N., et al. 2020. J Biol Chem. 295: 17659-17671. PMID: 33454005
- Salsalate reduces atherosclerosis through AMPKβ1 in mice. | Day, EA., et al. 2021. Mol Metab. 53: 101321. PMID: 34425254
- Circadian rhythm modulates endochondral bone formation via MTR1/AMPKβ1/BMAL1 signaling axis. | Yu, S., et al. 2022. Cell Death Differ. 29: 874-887. PMID: 35094018
- The phosphorylation of AMPKβ1 is critical for increasing autophagy and maintaining mitochondrial homeostasis in response to fatty acids. | Desjardins, EM., et al. 2022. Proc Natl Acad Sci U S A. 119: e2119824119. PMID: 36409897
- Blocking AMPK β1 myristoylation enhances AMPK activity and protects mice from high-fat diet-induced obesity and hepatic steatosis. | Neopane, K., et al. 2022. Cell Rep. 41: 111862. PMID: 36543129
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
AMPKβ1 Antibody (142A2R) | sc-517606 | 100 µg/ml | $316.00 |