Amphiregulin Antibody (C-1): sc-393433
- Amphiregulin Antibody (C-1) is a mouse monoclonal IgG2a κ, cited in 1 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 161-185 near the C-terminus of Amphiregulin of human origin
- recommended for detection of precursor and mature Amphiregulin of mouse, rat and human origin by WB, IP, IF and ELISA
- See Amphiregulin (G-4): sc-74501 for Amphiregulin antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Amphiregulin Antibody (C-1) for WB applications. These reagents are now offered in bundles with Amphiregulin Antibody (C-1) (see ordering information below).
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Amphiregulin Antibody (C-1) is a mouse monoclonal IgG2a light chain antibody that detects Amphiregulin in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Amphiregulin is a member of the epidermal growth factor (EGF) family and plays a crucial role in normal human keratinocyte proliferation, acting as an autocrine growth factor produced and secreted by keratinocytes. Amphiregulin binds to the ErbB-1 receptor, which is vital for epithelial development in various tissues, including the skin, lung, and gastrointestinal tract. Notably, Amphiregulin′s involvement in cellular processes extends to its influence on telomerase activity; withdrawal of Amphiregulin has been shown to downregulate telomerase in human keratinocytes, indicating its significant role in regulating cell senescence. Anti-Amphiregulin antibody (C-1) serves as an essential tool for researchers studying epithelial development and the mechanisms of keratinocyte growth and differentiation, providing insights into the complex signaling pathways that govern these processes.
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Amphiregulin Antibody (C-1) References:
- Amphiregulin as a driver of tissue fibrosis. | Zaiss, DMW. 2020. Am J Transplant. 20: 631-632. PMID: 31833651
- Amphiregulin Regulates Melanocytic Senescence. | Pommer, M., et al. 2021. Cells. 10: PMID: 33562468
- Amphiregulin induces CCN2 and fibronectin expression by TGF-β through EGFR-dependent pathway in lung epithelial cells. | Cheng, WH., et al. 2022. Respir Res. 23: 381. PMID: 36578010
- The role of amphiregulin in ovarian function and disease. | Fang, L., et al. 2023. Cell Mol Life Sci. 80: 60. PMID: 36749397
- Amphiregulin couples IL1RL1+ regulatory T cells and cancer-associated fibroblasts to impede antitumor immunity. | Sun, R., et al. 2023. Sci Adv. 9: eadd7399. PMID: 37611111
- Glutamine metabolism controls amphiregulin-facilitated chemoresistance to cisplatin in human chondrosarcoma. | Wu, YY., et al. 2023. Int J Biol Sci. 19: 5174-5186. PMID: 37928274
- Granzyme K- and amphiregulin-expressing cytotoxic T cells and activated extrafollicular B cells are potential drivers of IgG4-related disease. | Koga, R., et al. 2024. J Allergy Clin Immunol. 153: 1095-1112. PMID: 38092138
- Amphiregulin improves ventricular remodeling after myocardial infarction by modulating autophagy and apoptosis. | Li, N., et al. 2024. FASEB J. 38: e23488. PMID: 38358359
- Amphiregulin Switches Progenitor Cell Fate for Lineage Commitment During Gastric Mucosal Regeneration. | Lee, SH., et al. 2024. Gastroenterology. 167: 469-484. PMID: 38492892
- Stress-induced Rab11a-exosomes induce amphiregulin-mediated cetuximab resistance in colorectal cancer. | Mason, JD., et al. 2024. J Extracell Vesicles. 13: e12465. PMID: 38887984
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Amphiregulin Antibody (C-1) | sc-393433 | 200 µg/ml | $322.00 | |||
Amphiregulin Antibody (C-1): m-IgG Fc BP-HRP Bundle | sc-538215 | 200 µg Ab; 10 µg BP | $361.00 | |||
Amphiregulin Antibody (C-1): m-IgGκ BP-HRP Bundle | sc-535783 | 200 µg Ab; 40 µg BP | $361.00 | |||
Amphiregulin Antibody (C-1): m-IgG2a BP-HRP Bundle | sc-548234 | 200 µg Ab; 10 µg BP | $361.00 | |||
Amphiregulin (C-1) Neutralizing Peptide | sc-393433 P | 100 µg/0.5 ml | $69.00 |