Amphiphysin I Antibody (C-1): sc-376397
- Amphiphysin I Antibody (C-1) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 2-20 at the N-terminus of Amphiphysin of human origin
- recommended for detection of Amphiphysin I of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for Amphiphysin I Antibody (C-1) for WB applications. These reagents are now offered in bundles with Amphiphysin I Antibody (C-1) (see ordering information below).
QUICK LINKS
Amphiphysin I Antibody (C-1) is a mouse monoclonal IgG1 antibody that detects Amphiphysin I in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Amphiphysin I is a crucial brain-enriched protein that plays a significant role in synaptic vesicle recycling, a process vital for neurotransmission. Anti-Amphiphysin I antibody (C-1) functions as a dimer and features a unique structure that includes a membrane-bending BAR domain, a central Clathrin and adaptor binding domain, and a C-terminal SH3 domain. The interaction between Amphiphysin I and the GTPase Dynamin, mediated by the SH3 domain, is essential for the proper binding of Dynamin to Clathrin-coated pits, facilitating vesicle budding and release at synapses. In addition to its role in the brain, Amphiphysin I is also implicated in membrane bending and curvature stabilization in various tissues, highlighting its importance in cellular dynamics. Notably, the mammalian Amphiphysins, including Amphiphysin I and its splice variant Amphiphysin II, share a similar overall structure, yet they exhibit distinct functional roles, particularly in muscle tissue where a splice form of Amphiphysin II contributes to the formation and stabilization of the T tubule network. Amphiphysin I monoclonal antibody (C-1) is an invaluable tool for researchers studying synaptic function and membrane dynamics across different biological systems.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Amphiphysin I Antibody (C-1) | sc-376397 | 200 µg/ml | $322.00 | |||
Amphiphysin I Antibody (C-1): m-IgG Fc BP-HRP Bundle | sc-540565 | 200 µg Ab; 10 µg BP | $361.00 | |||
Amphiphysin I Antibody (C-1): m-IgG1 BP-HRP Bundle | sc-542210 | 200 µg Ab; 20 µg BP | $361.00 | |||
Amphiphysin I (C-1) Neutralizing Peptide | sc-376397 P | 100 µg/0.5 ml | $69.00 |