Amphiphysin I Antibody (B-6): sc-390338

Amphiphysin I Antibody (B-6) is a mouse monoclonal IgM antibody that detects Amphiphysin I in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Amphiphysin I is a crucial brain-enriched protein that plays a significant role in synaptic vesicle recycling, a process vital for neurotransmission. Anti-Amphiphysin I antibody (B-6) functions as a dimer and features a unique structure that includes a membrane-bending BAR domain, a central Clathrin and adaptor binding domain, and a C-terminal SH3 domain. The interaction of Amphiphysin I with the GTPase Dynamin via its SH3 domain is essential for the proper functioning of synaptic vesicles, as Amphiphysin I facilitates the binding of Dynamin to Clathrin-coated pits, leading to vesicle budding. This mechanism is not only critical for neuronal communication but also highlights Amphiphysin I′s importance in maintaining synaptic integrity. In addition to a role in the brain, Amphiphysin I′s structural characteristics allow participation in various membrane bending and curvature stabilization events across different tissues, underscoring Amphiphysin I′s versatility and significance in cellular processes. Anti-Amphiphysin I antibody (B-6) serves as an invaluable tool for researchers studying synaptic dynamics and related neurological functions.

The preferred Amphiphysin I antibody is Amphiphysin I Antibody (G-4): sc-376402.