Aminoacylase-1 Antibody (B-4): sc-374298

Aminoacylase-1 Antibody (B-4) is a mouse monoclonal IgG2b antibody that detects Aminoacylase-1 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Aminoacylase-1, also known as N-acyl-L-amino-acid amidohydrolase or ACY-1, is a crucial enzyme belonging to the metallopeptidase family M20A, characterized by its zinc-binding homodimeric structure. This enzyme is predominantly localized in the cytoplasm and plays a vital role in the hydrolysis of N-acylated or N-acetylated amino acids, which is essential for amino acid metabolism and cellular function. Aminoacylase-1 interacts with sphingosine kinase 1 (SphK1), suggesting a potential role in modulating cellular responses to oxidative stress. The gene encoding Aminoacylase-1 is evolutionarily conserved across various species, including fish, frogs, mice, rats, and humans, highlighting its fundamental biological significance. Notably, deficiencies in Aminoacylase-1 can lead to metabolic and functional defects in the brain, underscoring the necessity of this protein in maintaining neurological health. Anti-Aminoacylase-1 antibody (B-4) serves as an invaluable tool for researchers investigating the roles of this important enzyme in various biological contexts.

The preferred Aminoacylase-1 antibody is Aminoacylase-1 Antibody (B-1): sc-271019.