Aminoacylase-1 Antibody (A-5): sc-271705

Aminoacylase-1 Antibody (A-5) is a mouse monoclonal IgG2b antibody that detects Aminoacylase-1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Aminoacylase-1, also known as N-acyl-L-amino-acid amidohydrolase or ACY-1, is a crucial enzyme belonging to the M20A metallopeptidase family, characterized by its zinc-binding homodimeric structure. Aminoacylase-1 is predominantly localized in the cytoplasm and plays a vital role in the hydrolysis of N-acylated or N-acetylated amino acids, which is essential for amino acid metabolism and cellular function. Notably, Aminoacylase-1 interacts with sphingosine kinase 1 (SphK1), suggesting involvement in cellular responses to oxidative stress, a critical factor in various pathological conditions. The gene encoding Aminoacylase-1 is evolutionarily conserved across multiple species, including fish, frogs, mice, rats, and humans, highlighting fundamental biological importance. Deficiencies in Aminoacylase-1 can lead to significant metabolic and functional impairments in the brain, underscoring the necessity of this enzyme in maintaining neurological health. Anti-Aminoacylase-1 antibody (A-5) is an invaluable tool for researchers investigating the roles of this enzyme in health and disease.

The preferred Aminoacylase-1 antibody is Aminoacylase-1 Antibody (B-1): sc-271019.