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ALS2CL Antibody (E-8) is a mouse monoclonal IgG2a antibody that detects ALS2CL of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ALS2CL (E-8) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. ALS2CL plays a crucial role in modulating the activity of Rab5, a key regulator of the endocytic pathway, which is essential for cellular uptake of nutrients and signaling molecules. By influencing Rab5 activity, ALS2CL is involved in the dynamics of membrane trafficking and endocytosis, processes that are vital for maintaining cellular homeostasis and responding to environmental changes. Mutations in the ALS2 gene, which encodes the Alsin protein, are linked to several juvenile recessive motor neuron diseases, including juvenile primary lateral sclerosis and infantile onset ascending hereditary spastic paralysis. ALS2CL, by modulating Rab5, may also have implications in the pathophysiology of these diseases, highlighting its importance in both normal cellular function and disease mechanisms.
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Ordering Information
Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ALS2CL Antibody (E-8) | sc-377278 | 200 µg/ml | $316.00 | |||
ALS2CL Antibody (E-8): m-IgGκ BP-HRP Bundle | sc-523262 | 200 µg Ab, 40 µg BP | $354.00 | |||
ALS2CL Antibody (E-8) AC | sc-377278 AC | 500 µg/ml, 25% agarose | $416.00 | |||
ALS2CL Antibody (E-8) HRP | sc-377278 HRP | 200 µg/ml | $316.00 | |||
ALS2CL Antibody (E-8) FITC | sc-377278 FITC | 200 µg/ml | $330.00 | |||
ALS2CL Antibody (E-8) PE | sc-377278 PE | 200 µg/ml | $343.00 | |||
ALS2CL Antibody (E-8) Alexa Fluor® 488 | sc-377278 AF488 | 200 µg/ml | $357.00 | |||
ALS2CL Antibody (E-8) Alexa Fluor® 546 | sc-377278 AF546 | 200 µg/ml | $357.00 | |||
ALS2CL Antibody (E-8) Alexa Fluor® 594 | sc-377278 AF594 | 200 µg/ml | $357.00 | |||
ALS2CL Antibody (E-8) Alexa Fluor® 647 | sc-377278 AF647 | 200 µg/ml | $357.00 | |||
ALS2CL Antibody (E-8) Alexa Fluor® 680 | sc-377278 AF680 | 200 µg/ml | $357.00 | |||
ALS2CL Antibody (E-8) Alexa Fluor® 790 | sc-377278 AF790 | 200 µg/ml | $357.00 |