ALR Antibody (C-3): sc-365886

ALR Antibody (C-3) is a mouse monoclonal IgG1 antibody that detects ALR (augmenter of liver regeneration) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ALR is a crucial hepatotrophic growth factor and flavin-linked sulfhydryl oxidase that plays a significant role in liver regeneration and cellular iron homeostasis. ALR exists as a homodimer and is part of the Erv1/ALR family of proteins, which are found across various eukaryotic organisms. ALR has two distinct forms: a cytosolic form involved in the biogenesis of iron-sulfur proteins and a nuclear form that regulates the transcriptional activity of the AP-1 complex. The nuclear form′s ability to modulate gene expression is vital for cellular responses to stress and growth signals. Additionally, ALR enhances the expression of key enzymes such as S-adenosylmethionine decarboxylase and ornithine decarboxylase, which are essential for polyamine synthesis. This regulation of polyamines is critical for the different stages of liver regeneration, highlighting ALR′s importance in maintaining liver health and function. With broad species reactivity and versatility in various applications, anti-ALR antibody (C-3) serves as an invaluable tool for researchers studying liver biology and regeneration mechanisms.

The preferred ALR antibody is ALR Antibody (E-7): sc-365885.