αB-crystallin Antibody (C-8): sc-137144

αB-crystallin Antibody (C-8) is a mouse monoclonal IgG1 antibody that detects αB-crystallin in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). αB-crystallin monoclonal antibody (C-8) recognizes a member of the small heat shock protein family that plays a crucial role in cellular stress response by acting as a molecular chaperone, preventing the aggregation of denatured proteins and maintaining cellular protein homeostasis. This function is particularly important in tissues subject to high levels of stress, such as the lens of the eye, heart, and skeletal muscle, where αB-crystallin is abundantly expressed. Notably, elevated levels of αB-crystallin have been linked to various neurological diseases, highlighting αB-crystallin′s potential as a biomarker for disease progression. Additionally, mutations in the αB-crystallin gene have been associated with Desmin-related myopathy, underscoring αB-crystallin′s significance in muscle integrity and function. Anti-αB-crystallin antibody (C-8) serves as an essential tool for researchers investigating αB-crystallin′s role in health and disease, providing reliable detection and characterization in various experimental settings.

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αB-crystallin Antibody (C-8) References:

1. Enhanced stability of alpha B-crystallin in the presence of small heat shock protein Hsp27.  |  Fu, L. and Liang, JJ. 2003. Biochem Biophys Res Commun. 302: 710-4. PMID: 12646227
2. Alpha B-crystallin in cardiac tissue. Association with actin and desmin filaments.  |  Bennardini, F., et al. 1992. Circ Res. 71: 288-94. PMID: 1628387
3. Increased alpha-B-crystallin expression in mammary metaplastic carcinomas.  |  Chan, SK., et al. 2011. Histopathology. 59: 247-55. PMID: 21884203
4. Alpha B-crystallin is a new prognostic marker for laryngeal squamous cell carcinoma.  |  Mao, Y., et al. 2012. J Exp Clin Cancer Res. 31: 101. PMID: 23231769
5. Level of vitreous alpha-B crystallin in eyes with rhegmatogenous retinal detachment.  |  Baba, T., et al. 2015. Graefes Arch Clin Exp Ophthalmol. 253: 1251-4. PMID: 25311653
6. Alpha B-crystallin correlates with poor survival in colorectal cancer.  |  Shi, C., et al. 2014. Int J Clin Exp Pathol. 7: 6056-63. PMID: 25337251
7. Alpha B-crystallin promotes the invasion and metastasis of colorectal cancer via epithelial-mesenchymal transition.  |  Shi, C., et al. 2017. Biochem Biophys Res Commun. 489: 369-374. PMID: 28506831
8. Alpha B-Crystallin Overexpression Protects Oligodendrocyte Precursor Cells Against Oxidative Stress-Induced Apoptosis Through the Akt Pathway.  |  Kim, JY., et al. 2020. J Mol Neurosci. 70: 751-758. PMID: 31970633
9. Mature human induced pluripotent stem cell-derived cardiomyocytes promote angiogenesis through alpha-B crystallin.  |  Tanaka, Y., et al. 2023. Stem Cell Res Ther. 14: 240. PMID: 37679796
10. Alpha B-crystallin Ameliorates Imbalance of Redox Homeostasis, Inflammation and Apoptosis in an Acute Lung Injury Model with Rats.  |  Kocak, S., et al. 2024. Medeni Med J. 39: 211-220. PMID: 39350576

The preferred αB-crystallin antibody is αB-crystallin Antibody (F-10): sc-137129.