αB-crystallin Antibody (A-4): sc-365088
- αB-crystallin Antibody (A-4) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 115-147 within an internal region of αB-crystallin of human origin
- recommended for detection of αB-crystallin of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including porcine
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for αB-crystallin Antibody (A-4) for WB applications. These reagents are now offered in bundles with αB-crystallin Antibody (A-4) (see ordering information below).
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αB-crystallin Antibody (A-4) is a mouse monoclonal IgG1 antibody that detects αB-crystallin in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). αB-crystallin is a member of the small heat shock protein family and plays a crucial role in cellular stress response by acting as a molecular chaperone, preventing the aggregation of denatured proteins and maintaining cellular protein homeostasis. This function is particularly important in tissues subject to high levels of stress, such as the lens of the eye, heart, and skeletal muscle, where αB-crystallin is abundantly expressed. Notably, elevated levels of αB-crystallin have been linked to various neurological diseases, highlighting αB-crystallin′s potential as a biomarker for disease progression. Additionally, mutations in the αB-crystallin gene have been associated with Desmin-related myopathy, underscoring αB-crystallin′s significance in muscle integrity and function. Anti-αB-crystallin antibody (A-4) provides reliable detection and characterization in various experimental settings for researchers investigating αB-crystallin′s role in health and disease.
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αB-crystallin Antibody (A-4) References:
- Alpha B-crystallin is a major component of glial cytoplasmic inclusions in multiple system atrophy. | Pountney, DL., et al. 2005. Neurotox Res. 7: 77-85. PMID: 15639800
- (alpha)B-crystallin in cerebrospinal fluid of patients with multiple sclerosis. | Stoevring, B., et al. 2005. Clin Chim Acta. 356: 95-101. PMID: 15878466
- Alpha B-crystallin mutation in dilated cardiomyopathy. | Inagaki, N., et al. 2006. Biochem Biophys Res Commun. 342: 379-86. PMID: 16483541
- Increased neuronal expression of alpha B-crystallin in human olivary hypertrophy. | Fukushima, K., et al. 2006. Neuropathology. 26: 196-200. PMID: 16771174
- alpha B-crystallin is a cytoplasmic interaction partner of the kidney-specific cadherin-16. | Thedieck, C., et al. 2008. J Mol Biol. 378: 145-53. PMID: 18343407
- Expression and prognostic significance of the alpha B-crystallin gene in human hepatocellular carcinoma. | Tang, Q., et al. 2009. Hum Pathol. 40: 300-5. PMID: 18992912
- An examination of alpha B-crystallin as a modifier of SOD1 aggregate pathology and toxicity in models of familial amyotrophic lateral sclerosis. | Karch, CM. and Borchelt, DR. 2010. J Neurochem. 113: 1092-100. PMID: 20067574
- Alpha B-crystallin is expressed in non-lenticular tissues and accumulates in Alexander's disease brain. | Iwaki, T., et al. 1989. Cell. 57: 71-8. PMID: 2539261
- Differential expression of alpha A- and alpha B-crystallin during murine ocular development. | Robinson, ML. and Overbeek, PA. 1996. Invest Ophthalmol Vis Sci. 37: 2276-84. PMID: 8843924
- Alpha B-crystallin is associated with intermediate filaments in astrocytoma cells. | Wisniewski, T. and Goldman, JE. 1998. Neurochem Res. 23: 385-92. PMID: 9482251
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
αB-crystallin Antibody (A-4) | sc-365088 | 200 µg/ml | $316.00 | |||
αB-crystallin Antibody (A-4): m-IgG Fc BP-HRP Bundle | sc-540308 | 200 µg Ab; 10 µg BP | $354.00 | |||
αB-crystallin Antibody (A-4): m-IgG1 BP-HRP Bundle | sc-542030 | 200 µg Ab; 20 µg BP | $354.00 | |||
αB-crystallin (A-4) Neutralizing Peptide | sc-365088 P | 100 µg/0.5 ml | $68.00 |