α2ML1 Antibody (G-8): sc-393082
- α2ML1 Antibody (G-8) is a mouse monoclonal IgG1 κ α2ML1 antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 87-122 near the N-terminus of α2ML1 of human origin
- alpha 2ML1 Antibody (G-8) is recommended for detection of α2ML1 of human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-alpha 2ML1 Antibody (G-8) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for α2ML1 Antibody (G-8) for WB and IHC(P) applications. This reagent is now offered in a bundle with α2ML1 Antibody (G-8) (see ordering information below).
QUICK LINKS
SEE ALSO...
α2ML1 Antibody (G-8) is a mouse monoclonal IgG1 kappa light chain antibody that detects alpha 2ML1 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). α2ML1 (G-8) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Alpha-2-macroglobulin-like protein 1 (α2ML1) is primarily expressed in the epidermis and plays a crucial role in keratinocyte differentiation, which is essential for maintaining skin integrity and barrier function. This differentiation process helps protect against environmental stressors and pathogens, highlighting α2ML1′s importance in skin health and disease. α2ML1 may interact with various signaling pathways that regulate cellular responses during skin development and repair. Understanding α2ML1′s function and role in keratinocyte biology can provide insights into potential therapeutic targets for skin-related disorders.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
α2ML1 Antibody (G-8) References:
- Cloning of the human alpha 2-macroglobulin gene and detection of mutations in two functional domains: the bait region and the thiolester site. | Poller, W., et al. 1992. Hum Genet. 88: 313-9. PMID: 1370808
- A novel protease inhibitor of the alpha2-macroglobulin family expressed in the human epidermis. | Galliano, MF., et al. 2006. J Biol Chem. 281: 5780-9. PMID: 16298998
- Binding of IL-1 beta to alpha-macroglobulins and release by thioredoxin. | Borth, W., et al. 1990. J Immunol. 145: 3747-54. PMID: 1700994
- Binding of alpha2ML1 to the low density lipoprotein receptor-related protein 1 (LRP1) reveals a new role for LRP1 in the human epidermis. | Galliano, MF., et al. 2008. PLoS One. 3: e2729. PMID: 18648652
- Sequence analysis of the putative regulatory region of rat alpha 2-macroglobulin gene. | Tsuchiya, Y., et al. 1987. Gene. 57: 73-80. PMID: 2448189
- The interaction of alpha 2-macroglobulin with proteinases. Characteristics and specificity of the reaction, and a hypothesis concerning its molecular mechanism. | Barrett, AJ. and Starkey, PM. 1973. Biochem J. 133: 709-24. PMID: 4201304
- Localization of the binding site for transforming growth factor-beta in human alpha2-macroglobulin to a 20-kDa peptide that also contains the bait region. | Webb, DJ., et al. 1998. J Biol Chem. 273: 13339-46. PMID: 9582381
- Alpha-2 macroglobulin is genetically associated with Alzheimer disease. | Blacker, D., et al. 1998. Nat Genet. 19: 357-60. PMID: 9697696
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
α2ML1 Antibody (G-8) | sc-393082 | 200 µg/ml | $322.00 | |||
α2ML1 Antibody (G-8): m-IgG Fc BP-HRP Bundle | sc-526219 | 200 µg Ab; 10 µg BP | $361.00 | |||
α2ML1 Antibody (G-8) AC | sc-393082 AC | 500 µg/ml, 25% agarose | $424.00 | |||
α2ML1 Antibody (G-8) HRP | sc-393082 HRP | 200 µg/ml | $322.00 | |||
α2ML1 Antibody (G-8) FITC | sc-393082 FITC | 200 µg/ml | $336.00 | |||
α2ML1 Antibody (G-8) PE | sc-393082 PE | 200 µg/ml | $349.00 | |||
α2ML1 Antibody (G-8) Alexa Fluor® 488 | sc-393082 AF488 | 200 µg/ml | $364.00 | |||
α2ML1 Antibody (G-8) Alexa Fluor® 546 | sc-393082 AF546 | 200 µg/ml | $364.00 | |||
α2ML1 Antibody (G-8) Alexa Fluor® 594 | sc-393082 AF594 | 200 µg/ml | $364.00 | |||
α2ML1 Antibody (G-8) Alexa Fluor® 647 | sc-393082 AF647 | 200 µg/ml | $364.00 | |||
α2ML1 Antibody (G-8) Alexa Fluor® 680 | sc-393082 AF680 | 200 µg/ml | $364.00 | |||
α2ML1 Antibody (G-8) Alexa Fluor® 790 | sc-393082 AF790 | 200 µg/ml | $364.00 | |||
α2ML1 (G-8) Neutralizing Peptide | sc-393082 P | 100 µg/0.5 ml | $69.00 |