α_2B-AR Antibody (G-9): sc-390430

α2B-AR Antibody (G-9) is a mouse monoclonal IgG1 kappa light chain antibody that detects α2B-AR protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-α2B-AR antibody (G-9) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The alpha 2B-adrenergic receptor (α2B-AR) is a member of the G protein-coupled receptor superfamily, playing a pivotal role in regulating neurotransmitter release from sympathetic nerves and adrenergic neurons in the central nervous system. α2B-AR (G-9) antibody recognizes a receptor subtype particularly important in mediating physiological responses to catecholamines, such as norepinephrine, and is implicated in salt-dependent hypertension development. α2B-AR protein primarily localizes in the plasma membrane of cells, interacting with various intracellular signaling molecules, including guanine nucleotide exchange factor eIF-2B, which modulates downstream signaling pathways. α2B-AR transcripts show notable abundance in rat liver and kidney, highlighting significance in both peripheral and central nervous system functions. Research into α2B-AR in these tissues provides insights into cardiovascular regulation and potential therapeutic targets for hypertension and related disorders.

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α_2B-AR Antibody (G-9) References:

1. Polymorphic deletion of three intracellular acidic residues of the alpha 2B-adrenergic receptor decreases G protein-coupled receptor kinase-mediated phosphorylation and desensitization.  |  Small, KM., et al. 2001. J Biol Chem. 276: 4917-22. PMID: 11056163
2. alpha 2B-adrenergic receptor activates MAPK via a pathway involving arachidonic acid metabolism, matrix metalloproteinases, and epidermal growth factor receptor transactivation.  |  Cussac, D., et al. 2002. J Biol Chem. 277: 19882-8. PMID: 11891218
3. Molecular evolution of the mammalian alpha 2B adrenergic receptor.  |  Madsen, O., et al. 2002. Mol Biol Evol. 19: 2150-60. PMID: 12446807
4. Conserved motifs in somatostatin, D2-dopamine, and alpha 2B-adrenergic receptors for inhibiting the Na-H exchanger, NHE1.  |  Lin, CY., et al. 2003. J Biol Chem. 278: 15128-35. PMID: 12566440
5. Central alpha2B-adrenergic receptor antisense in plasmid vector prolongs reversal of salt-dependent hypertension.  |  Kintsurashvili, E., et al. 2003. J Hypertens. 21: 961-7. PMID: 12714871
6. Spinophilin stabilizes cell surface expression of alpha 2B-adrenergic receptors.  |  Brady, AE., et al. 2003. J Biol Chem. 278: 32405-12. PMID: 12738775
7. The alpha2B adrenergic receptor deletion/insertion polymorphism in morbid obesity.  |  Sykiotis, GP., et al. 2003. Clin Auton Res. 13: 203-7. PMID: 12822042
8. A deletion in the alpha2B-adrenergic receptor gene and autonomic nervous function in central obesity.  |  Sivenius, K., et al. 2003. Obes Res. 11: 962-70. PMID: 12917501
9. Variation in the alpha2B-adrenergic receptor gene (ADRA2B) and its relationship to vascular response in vivo.  |  Muszkat, M., et al. 2005. Pharmacogenet Genomics. 15: 407-14. PMID: 15900214
10. Cloning, expression, and pharmacological characterization of a human alpha 2B-adrenergic receptor.  |  Weinshank, RL., et al. 1990. Mol Pharmacol. 38: 681-8. PMID: 2172775
11. Alpha 2B-adrenergic receptors: immunolocalization and regulation by potassium depletion in rat kidney.  |  Huang, L., et al. 1996. Am J Physiol. 270: F1015-26. PMID: 8764321
12. A novel interaction between adrenergic receptors and the alpha-subunit of eukaryotic initiation factor 2B.  |  Klein, U., et al. 1997. J Biol Chem. 272: 19099-102. PMID: 9235896

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-α_2B-AR Antibody (G-9) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-α_2B-AR Antibody (G-9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

α_2B-AR Antibody (G-9) Specifications

Alternate Product Name: α2B-AR

Product Clone Name: G-9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 202-297

Epitope Target: α_2B-AR

Epitope Species: human

Product Reactivity/Detection: α_2B-AR

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for α_2B-AR Antibody (G-9): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin