α T-catenin Antibody (B-6): sc-398138
- α T-catenin Antibody (B-6) is a mouse monoclonal IgG1 κ α T-catenin antibody provided at 200 µg/ml
- raised against amino acids 61-125 mapping near the N-terminus of α T-catenin of human origin
- alpha T-catenin Antibody (B-6) is recommended for detection of α T-catenin of human origin by WB, IP, IF and ELISA
- Anti-alpha T-catenin Antibody (B-6) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for α T-catenin Antibody (B-6) for WB applications. These reagents are now offered in bundles with α T-catenin Antibody (B-6) (see ordering information below).
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α T-catenin Antibody (B-6) is a mouse monoclonal IgG1 kappa light chain antibody that detects alpha T-catenin of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-alpha T-catenin antibody (B-6) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Alpha T-catenin, also known as VR22, is a crucial component of the catenin family, which includes α, β, γ, and δ catenins that are widely expressed in various tissues. This 895-amino acid protein is predominantly found in cardiomyocytes and peritubular myoid cells of the testis, where alpha T-catenin plays a vital role in cellular adhesion by forming complexes with E-cadherin at cell junctions. Alpha T-catenin is involved in the regulation of Wnt signaling pathways through interactions with α E-catenin and β-catenin, which are essential for maintaining proper cellular communication and tissue integrity. The gene encoding alpha T-catenin, CTNNA3, is located on chromosome 10, and mutations in CTNNA3 have been linked to late-onset Alzheimer′s disease and dilated cardiomyopathy, highlighting alpha T-catenin′s significance in both neurodegenerative and cardiovascular health.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
α T-catenin Antibody (B-6) References:
- Linkage of plasma Abeta42 to a quantitative locus on chromosome 10 in late-onset Alzheimer's disease pedigrees. | Ertekin-Taner, N., et al. 2000. Science. 290: 2303-4. PMID: 11125143
- alphaT-catenin: a novel tissue-specific beta-catenin-binding protein mediating strong cell-cell adhesion. | Janssens, B., et al. 2001. J Cell Sci. 114: 3177-88. PMID: 11590244
- Assessment of the CTNNA3 gene encoding human alpha T-catenin regarding its involvement in dilated cardiomyopathy. | Janssens, B., et al. 2003. Hum Genet. 112: 227-36. PMID: 12596047
- Fine mapping of the alpha-T catenin gene to a quantitative trait locus on chromosome 10 in late-onset Alzheimer's disease pedigrees. | Ertekin-Taner, N., et al. 2003. Hum Mol Genet. 12: 3133-43. PMID: 14559775
- Genetic variation in CTNNA3 encoding alpha-3 catenin and Alzheimer's disease. | Blomqvist, ME., et al. 2004. Neurosci Lett. 358: 220-2. PMID: 15039120
- Alpha-T-catenin is expressed in human brain and interacts with the Wnt signaling pathway but is not responsible for linkage to chromosome 10 in Alzheimer's disease. | Busby, V., et al. 2004. Neuromolecular Med. 5: 133-46. PMID: 15075440
- Interaction between the alpha-T catenin gene (VR22) and APOE in Alzheimer's disease. | Martin, ER., et al. 2005. J Med Genet. 42: 787-92. PMID: 16199552
- Dynamin-binding protein gene on chromosome 10q is associated with late-onset Alzheimer's disease. | Kuwano, R., et al. 2006. Hum Mol Genet. 15: 2170-82. PMID: 16740596
- Parsing the genetic heterogeneity of chromosome 12q susceptibility genes for Alzheimer disease by family-based association analysis. | Lin, PI., et al. 2006. Neurogenetics. 7: 157-65. PMID: 16770605
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
α T-catenin Antibody (B-6) | sc-398138 | 200 µg/ml | $316.00 | |||
α T-catenin Antibody (B-6): m-IgG Fc BP-HRP Bundle | sc-530702 | 200 µg Ab; 10 µg BP | $354.00 | |||
α T-catenin Antibody (B-6): m-IgGκ BP-HRP Bundle | sc-524229 | 200 µg Ab, 40 µg BP | $354.00 | |||
α T-catenin Antibody (B-6): m-IgG1 BP-HRP Bundle | sc-544209 | 200 µg Ab; 20 µg BP | $354.00 | |||
α T-catenin Antibody (B-6) AC | sc-398138 AC | 500 µg/ml, 25% agarose | $416.00 | |||
α T-catenin Antibody (B-6) HRP | sc-398138 HRP | 200 µg/ml | $316.00 | |||
α T-catenin Antibody (B-6) FITC | sc-398138 FITC | 200 µg/ml | $330.00 | |||
α T-catenin Antibody (B-6) PE | sc-398138 PE | 200 µg/ml | $343.00 | |||
α T-catenin Antibody (B-6) Alexa Fluor® 488 | sc-398138 AF488 | 200 µg/ml | $357.00 | |||
α T-catenin Antibody (B-6) Alexa Fluor® 546 | sc-398138 AF546 | 200 µg/ml | $357.00 | |||
α T-catenin Antibody (B-6) Alexa Fluor® 594 | sc-398138 AF594 | 200 µg/ml | $357.00 | |||
α T-catenin Antibody (B-6) Alexa Fluor® 647 | sc-398138 AF647 | 200 µg/ml | $357.00 | |||
α T-catenin Antibody (B-6) Alexa Fluor® 680 | sc-398138 AF680 | 200 µg/ml | $357.00 | |||
α T-catenin Antibody (B-6) Alexa Fluor® 790 | sc-398138 AF790 | 200 µg/ml | $357.00 |