α T-catenin Antibody (4A21): sc-69968

α T-catenin Antibody (4A21) is a mouse monoclonal IgG2a antibody that detects α T-catenin in mouse, rat, and human samples through applications such as western blotting (WB) and immunofluorescence (IF). α T-catenin, also known as VR22, is a crucial 895-amino acid protein predominantly expressed in cardiomyocytes and peritubular myoid cells of the testis, where α T-catenin plays a vital role in cellular adhesion by forming complexes with E-cadherin at cellular junctions. These catenin/cadherin complexes are essential for maintaining tissue integrity and regulating cell signaling pathways, particularly in inhibiting Wnt signaling, which is important for various developmental processes and cellular functions. The gene encoding α T-catenin, CTNNA3, is located on chromosome 10, and mutations in this gene have been linked to significant health issues, including late-onset Alzheimer′s disease and dilated cardiomyopathy, highlighting α T-catenin′s importance in both neurodegenerative and cardiac conditions. With insights into these critical biological processes, anti-α T-catenin antibody (4A21) serves as an invaluable tool for researchers studying cell adhesion mechanisms and their implications in disease.

The preferred α T-catenin antibody is α T-catenin Antibody (B-6): sc-398138.