alpha Synuclein Antibody (Syn 204): sc-32280

α-synuclein Antibody (Syn 204) is a mouse monoclonal IgG2a kappa light chain antibody designed to recognize the human α-synuclein protein, also known as SNCA or NACP. α-synuclein monoclonal antibody (Syn 204) targets human recombinant α-synuclein and is effective in applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP). α-synuclein is predominantly located in the cytoplasm of neuronal cell bodies and presynaptic terminals, where α-synuclein plays a critical role in regulating synaptic vesicle trafficking and neurotransmitter release, essential processes for efficient neuronal communication and plasticity. The precise localization of α-synuclein within neurons is vital for maintaining synaptic function and neuronal health, making α-synuclein a key protein in understanding synaptic regulation. Additionally, α-synuclein is implicated in the pathogenesis of several neurodegenerative diseases, including Parkinson′s disease, where abnormal aggregation leads to the formation of Lewy bodies, and Alzheimer′s disease, where α-synuclein is a component of amyloid plaques. Beyond the nervous system, α-synuclein expression is modulated during hematopoietic cell differentiation, highlighting broader significance in cellular processes. α-synuclein (Syn 204) antibody is available in both unconjugated form and various conjugated forms such as horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates, providing versatile options for diverse experimental needs. α-synuclein (Syn 204) monoclonal antibody is an essential tool for researchers investigating the molecular mechanisms underlying synuclein-related disorders and exploring the physiological functions of α-synuclein in both neuronal and hematopoietic cells.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-alpha Synuclein Antibody (Syn 204) has 9 citations in a variety of scientific publications.

Primary antibodies like Anti-alpha Synuclein Antibody (Syn 204) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

alpha Synuclein Antibody (Syn 204) Specifications

Alternate Product Name: alpha synuclein

Product Clone Name: Syn 204

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids:

Epitope Target: α-synuclein

Epitope Species: human

Product Reactivity/Detection: α-synuclein

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P)

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 9 citations in various scientific publications

Available Conjugates/Forms for alpha Synuclein Antibody (Syn 204): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred alpha Synuclein antibody is alpha Synuclein Antibody (211): sc-12767.