alpha Synuclein Antibody (LB 509): sc-58480

α-synuclein Antibody (LB 509) is a mouse monoclonal IgG1 kappa light chain antibody developed to detect human α-synuclein protein, also known as SNCA or NACP, through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP) applications. α-synuclein monoclonal antibody (LB 509) targets α-synuclein associated with Lewy bodies, which are abnormal aggregates found in the brains of individuals with neurodegenerative diseases. α-synuclein (LB 509) antibody recognizes α-synuclein predominantly expressed in neuronal cell bodies and synapses, where α-synuclein plays a crucial role in regulating synaptic vesicle trafficking and neurotransmitter release, essential processes for maintaining efficient neuronal communication and plasticity. α-synuclein (LB 509) monoclonal antibody detects α-synuclein that can interact with membranes and form dynamic structures vital for normal function, but when misfolded, can aggregate into insoluble fibrils implicated in the pathogenesis of Parkinson′s disease and Alzheimer′s disease. Understanding α-synuclein function and regulation is important for elucidating mechanisms underlying these debilitating disorders and developing potential therapeutic strategies. α-synuclein (LB 509) antibody is available in both unconjugated form and various conjugated forms, including horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates, offering versatile options for diverse experimental needs. α-synuclein (LB 509) monoclonal antibody is an essential tool for advancing our understanding of α-synuclein′s role in neuronal health and disease, facilitating breakthroughs in the study and treatment of synucleinopathies.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-alpha Synuclein Antibody (LB 509) has 29 citations in a variety of scientific publications.

Primary antibodies like Anti-alpha Synuclein Antibody (LB 509) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

alpha Synuclein Antibody (LB 509) Specifications

Alternate Product Name: alpha synuclein

Product Clone Name: LB 509

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: α-synuclein

Epitope Species: human

Product Reactivity/Detection: α-synuclein

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P)

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 29 citations in various scientific publications

Available Conjugates/Forms for alpha Synuclein Antibody (LB 509): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred alpha Synuclein antibody is alpha Synuclein Antibody (211): sc-12767.