alpha Synuclein Antibody (3H2897): sc-69977

α-synuclein Antibody (3H2897) is a mouse monoclonal IgG1 kappa light chain antibody developed to detect α-synuclein, also known as SNCA or NACP, in mouse, rat, and human samples using western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP) techniques. α-synuclein monoclonal antibody (3H2897) targets recombinant α-synuclein of human origin and is instrumental in studying the protein′s various post-translational modifications, which are critical for understanding its function and role in disease. α-synuclein is predominantly expressed in the brain, particularly within neuronal cell bodies and synapses, where α-synuclein plays a vital role in synaptic vesicle trafficking and neurotransmitter release, essential processes for effective neuronal communication and plasticity. Post-translational modifications of α-synuclein, such as phosphorylation, ubiquitination, and nitration, significantly influence structural conformation and aggregation propensity. These modifications are important because they can alter normal function and promote the formation of pathological aggregates, including Lewy bodies, which are characteristic of Parkinson′s disease and implicated in Alzheimer′s disease. Understanding these modifications helps elucidate the mechanisms underlying synucleinopathies and facilitates the development of targeted therapeutic strategies to prevent or reduce aggregation. α-synuclein (3H2897) antibody is available in an unconjugated form, providing flexibility for various experimental applications. α-synuclein monoclonal antibody (3H2897) is an essential tool for advancing the study of α-synuclein′s role in maintaining neuronal health and involvement in the pathogenesis of debilitating neurodegenerative disorders.

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-alpha Synuclein Antibody (3H2897) has 40 citations in a variety of scientific publications.

Primary antibodies like Anti-alpha Synuclein Antibody (3H2897) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

alpha Synuclein Antibody (3H2897) Specifications

Alternate Product Name: alpha synuclein

Product Clone Name: 3H2897

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: α-synuclein

Epitope Species: human

Product Reactivity/Detection: α-synuclein

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P)

Vialing Information: Each vial contains 50 µg IgG₁ in 500 µl of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 40 citations in various scientific publications

Available Conjugates/Forms for alpha Synuclein Antibody (3H2897): N/A

The preferred alpha Synuclein antibody is alpha Synuclein Antibody (211): sc-12767.