alpha Synuclein Antibody (2B2D1): sc-53955

α-synuclein Antibody (2B2D1) is a mouse monoclonal IgG1 kappa light chain antibody developed to detect α-synuclein, also known as SNCA or NACP, in mouse, rat, and human samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP) applications. α-synuclein monoclonal antibody (2B2D1) targets α-synuclein, a protein primarily localized in the cytoplasm of neuronal cell bodies and presynaptic terminals, where α-synuclein plays a crucial role in regulating synaptic vesicle trafficking and neurotransmitter release, essential for effective neuronal communication and plasticity. The specific localization of α-synuclein within these cellular compartments is vital for maintaining synaptic function and overall neuronal health, as any disruption can lead to impaired neurotransmission and contribute to the development of neurodegenerative diseases. In pathological states such as Parkinson′s disease and Alzheimer′s disease, α-synuclein mislocalizes and aggregates, forming Lewy bodies and contributing to neuronal dysfunction and cell death. Understanding the precise cellular distribution of α-synuclein is therefore essential for elucidating normal physiological roles and involvement in disease mechanisms. α-synuclein (2B2D1) antibody is available in both unconjugated form and various conjugated forms, including horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. α-synuclein (2B2D1) monoclonal antibody is an essential tool for scientists investigating the intricate roles of α-synuclein in both healthy and diseased states, facilitating advancements in the understanding and treatment of debilitating neurodegenerative disorders.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-alpha Synuclein Antibody (2B2D1) has 8 citations in a variety of scientific publications.

Primary antibodies like Anti-alpha Synuclein Antibody (2B2D1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

alpha Synuclein Antibody (2B2D1) Specifications

Alternate Product Name: alpha synuclein

Product Clone Name: 2B2D1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: α-synuclein

Epitope Species: human

Product Reactivity/Detection: α-synuclein

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P)

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 8 citations in various scientific publications

Available Conjugates/Forms for alpha Synuclein Antibody (2B2D1): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred alpha Synuclein antibody is alpha Synuclein Antibody (211): sc-12767.