α-dystroglycan Antibody (IIH6): sc-53987

α-dystroglycan Antibody (IIH6) is a mouse monoclonal IgM antibody that detects α-dystroglycan of mouse, rat, human, rabbit, and canine origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. α-dystroglycan (IIH6) antibody is available as both non-conjugated and in various Alexa Fluor® conjugates. α-dystroglycan plays a crucial role as a cell surface receptor for several extracellular matrix molecules, including laminins, Agrin, and Perlecan, which are essential for basement membrane formation during early development and laminin organization on cell surfaces. α-dystroglycan′s location at cell membranes facilitates interaction with dystrophin and utrophin, forming dystrophin-associated protein complex and utrophin-associated protein complex, respectively. These complexes maintain structural integrity of muscle cells and cluster nicotinic acetylcholine receptors at neuromuscular junctions, essential for effective synaptic transmission. α-dystroglycan′s interactions with these proteins underscore α-dystroglycan (IIH6) monoclonal antibody′s value for researchers studying muscle biology and related disorders.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

α-dystroglycan Antibody (IIH6) References:

1. Chimaeric mice deficient in dystroglycans develop muscular dystrophy and have disrupted myoneural synapses.  |  Côté, PD., et al. 1999. Nat Genet. 23: 338-42. PMID: 10610181
2. Differential targeting of components of the dystrophin complex to the postsynaptic membrane.  |  Marchand, S., et al. 2001. Eur J Neurosci. 13: 221-9. PMID: 11168526
3. Distinct roles for dystroglycan, beta1 integrin and perlecan in cell surface laminin organization.  |  Henry, MD., et al. 2001. J Cell Sci. 114: 1137-44. PMID: 11228157
4. Expression of dystroglycan complex in satellite cells of dorsal root ganglia.  |  Masaki, T., et al. 2001. Acta Neuropathol. 101: 174-8. PMID: 11271373
5. Syntheses of alpha-dystroglycan derived glycosyl amino acids carrying a novel mannosyl serine/threonine linkage.  |  Seifert, J., et al. 2000. Glycoconj J. 17: 407-23. PMID: 11294507
6. Dystroglycan: a possible mediator for reducing congenital muscular dystrophy?  |  Sciandra, F., et al. 2007. Trends Biotechnol. 25: 262-8. PMID: 17416431
7. Inflammation and response to steroid treatment in limb-girdle muscular dystrophy 2I.  |  Darin, N., et al. 2007. Eur J Paediatr Neurol. 11: 353-7. PMID: 17446099
8. Expression of the murine Pomt1 gene in both the developing brain and adult muscle tissues and its relationship with clinical aspects of Walker-Warburg syndrome.  |  Prados, B., et al. 2007. Am J Pathol. 170: 1659-68. PMID: 17456771
9. Localized treatment with a novel FDA-approved proteasome inhibitor blocks the degradation of dystrophin and dystrophin-associated proteins in mdx mice.  |  Bonuccelli, G., et al. 2007. Cell Cycle. 6: 1242-8. PMID: 17495527
10. Small molecules enhance functional O-mannosylation of Alpha-dystroglycan.  |  Lv, F., et al. 2015. Bioorg Med Chem. 23: 7661-70. PMID: 26652968
11. Mechanistic aspects of the formation of α-dystroglycan and therapeutic research for the treatment of α-dystroglycanopathy: A review.  |  Taniguchi-Ikeda, M., et al. 2016. Mol Aspects Med. 51: 115-24. PMID: 27421908
12. GMPPA defects cause a neuromuscular disorder with α-dystroglycan hyperglycosylation.  |  Franzka, P., et al. 2021. J Clin Invest. 131: PMID: 33755596

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-α-dystroglycan Antibody (IIH6) has 32 citations in a variety of scientific publications.

Primary antibodies like Anti-α-dystroglycan Antibody (IIH6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

α-dystroglycan Antibody (IIH6) Specifications

Alternate Product Name: Alpha Dystroglycan

Product Clone Name: IIH6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids:

Epitope Target: α-dystroglycan

Epitope Species: rabbit

Product Reactivity/Detection: α-dystroglycan

Species Reactivity/Detection: mouse, rat, human, rabbit, canine

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P)

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 32 citations in various scientific publications

Available Conjugates/Forms for α-dystroglycan Antibody (IIH6): N/A