α-Dystrobrevin Antibody (E-12): sc-365289
- α-Dystrobrevin Antibody (E-12) is a mouse monoclonal IgG2b κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 351-371 within an internal region of α-Dystrobrevin of human origin
- recommended for detection of all isoforms of α-Dystrobrevin of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine, canine, bovine and porcine
- m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for α-Dystrobrevin Antibody (E-12) for WB applications. These reagents are now offered in bundles with α-Dystrobrevin Antibody (E-12) (see ordering information below).
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α-Dystrobrevin Antibody (E-12) is a mouse monoclonal IgG2b antibody that detects α-Dystrobrevin in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). α-Dystrobrevin is a crucial component of the dystrophin glycoprotein complex, playing a significant role in maintaining the structural integrity of muscle cells and facilitating synapse maturation, which is vital for normal muscle function and communication between nerve and muscle cells. α-Dystrobrevin is predominantly localized to the cytoplasmic side of the sarcolemma and is particularly concentrated at neuromuscular junctions in skeletal muscle, where α-Dystrobrevin helps anchor the dystrophin complex to the cell membrane. Disruptions in α-Dystrobrevin function can lead to severe muscle degeneration and various muscular dystrophies. Alternative splicing of α-Dystrobrevin results in several isoforms, including γ-Dystrobrevin, δ-Dystrobrevin, ε-Dystrobrevin, and ζ-Dystrobrevin, which may have distinct roles in different tissues, further emphasizing the complexity and significance of α-Dystrobrevin in muscle biology.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
α-Dystrobrevin Antibody (E-12) | sc-365289 | 200 µg/ml | $322.00 | |||
α-Dystrobrevin Antibody (E-12): m-IgGκ BP-HRP Bundle | sc-535182 | 200 µg Ab; 40 µg BP | $361.00 | |||
α-Dystrobrevin Antibody (E-12): m-IgG2b BP-HRP Bundle | sc-549355 | 200 µg Ab; 10 µg BP | $361.00 | |||
α-Dystrobrevin (E-12) Neutralizing Peptide | sc-365289 P | 100 µg/0.5 ml | $69.00 |