α-defensin 5 Antibody (8c8): sc-53997
- α-defensin 5 Antibody (8c8) is a mouse monoclonal IgG2b κ α-defensin 5 antibody, cited in 8 publications, provided at 200 µg/ml
- raised against α-Defensin 5 of human origin
- alpha-defensin 5 Antibody (8c8) is recommended for detection of α-defensin 5 of human origin by WB, IP and IF
- Anti-alpha-defensin 5 Antibody (8c8) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for α-defensin 5 Antibody (8c8) for WB applications. These reagents are now offered in bundles with α-defensin 5 Antibody (8c8) (see ordering information below).
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α-defensin 5 Antibody (8c8) is a mouse monoclonal IgG2b kappa light chain antibody that detects the alpha-defensin 5 protein of human origin by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). α-defensin 5 (8c8) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Alpha-defensin 5, a member of the human neutrophil defensins (HNPs), is a small, cationic, cysteine-rich antimicrobial peptide that plays a crucial role in the innate immune response, particularly in combating infectious agents such as bacteria, fungi, and enveloped viruses. Alpha-defensin 5 is synthesized as inactive precursors and requires proteolytic cleavage by matrix metalloproteinase-7 (MMP-7) for activation. Alpha-defensin 5 is secreted by Paneth cells located in the crypts of the small intestine, where alpha-defensin 5 is also referred to as cryptidin in mice. Alpha-defensin 5 is essential for maintaining the integrity of the gastrointestinal mucosal surface, especially during states of intestinal inflammation, as alpha-defensin 5 helps to protect against microbial invasion. Alpha-defensin 5′s ability to modulate the gut microbiome and influence local immune responses underscores alpha-defensin 5′s importance in gastrointestinal health and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
α-defensin 5 Antibody (8c8) References:
- Peptide localization and gene structure of cryptdin 4, a differentially expressed mouse paneth cell alpha-defensin. | Ouellette, AJ., et al. 1999. Infect Immun. 67: 6643-51. PMID: 10569786
- Expression of human alpha-defensin 5 (HD5) mRNA in nasal and bronchial epithelial cells. | Frye, M., et al. 2000. J Clin Pathol. 53: 770-3. PMID: 11064671
- Activation of Paneth cell alpha-defensins in mouse small intestine. | Ayabe, T., et al. 2002. J Biol Chem. 277: 5219-28. PMID: 11733520
- From pro defensins to defensins: synthesis and characterization of human neutrophil pro alpha-defensin-1 and its mature domain. | Wu, Z., et al. 2003. J Pept Res. 62: 53-62. PMID: 12823617
- Alpha-defensins in the gastrointestinal tract. | Cunliffe, RN. 2003. Mol Immunol. 40: 463-7. PMID: 14568393
- Functional analysis of the alpha-defensin disulfide array in mouse cryptdin-4. | Maemoto, A., et al. 2004. J Biol Chem. 279: 44188-96. PMID: 15297466
- Identification of defensin alpha6 as a potential biomarker in colon adenocarcinoma. | Nam, MJ., et al. 2005. J Biol Chem. 280: 8260-5. PMID: 15613481
- Human neutrophil alpha-defensin 4 inhibits HIV-1 infection in vitro. | Wu, Z., et al. 2005. FEBS Lett. 579: 162-6. PMID: 15620707
- Human alpha-defensins block papillomavirus infection. | Buck, CB., et al. 2006. Proc Natl Acad Sci U S A. 103: 1516-21. PMID: 16432216
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
α-defensin 5 Antibody (8c8) | sc-53997 | 200 µg/ml | $322.00 | |||
α-defensin 5 Antibody (8c8): m-IgGκ BP-HRP Bundle | sc-521005 | 200 µg Ab, 40 µg BP | $361.00 | |||
α-defensin 5 Antibody (8c8): m-IgG2b BP-HRP Bundle | sc-548859 | 200 µg Ab; 10 µg BP | $361.00 | |||
α-defensin 5 Antibody (8c8) AC | sc-53997 AC | 500 µg/ml, 25% agarose | $424.00 | |||
α-defensin 5 Antibody (8c8) HRP | sc-53997 HRP | 200 µg/ml | $322.00 | |||
α-defensin 5 Antibody (8c8) FITC | sc-53997 FITC | 200 µg/ml | $336.00 | |||
α-defensin 5 Antibody (8c8) PE | sc-53997 PE | 200 µg/ml | $349.00 | |||
α-defensin 5 Antibody (8c8) Alexa Fluor® 488 | sc-53997 AF488 | 200 µg/ml | $364.00 | |||
α-defensin 5 Antibody (8c8) Alexa Fluor® 546 | sc-53997 AF546 | 200 µg/ml | $364.00 | |||
α-defensin 5 Antibody (8c8) Alexa Fluor® 594 | sc-53997 AF594 | 200 µg/ml | $364.00 | |||
α-defensin 5 Antibody (8c8) Alexa Fluor® 647 | sc-53997 AF647 | 200 µg/ml | $364.00 | |||
α-defensin 5 Antibody (8c8) Alexa Fluor® 680 | sc-53997 AF680 | 200 µg/ml | $364.00 | |||
α-defensin 5 Antibody (8c8) Alexa Fluor® 790 | sc-53997 AF790 | 200 µg/ml | $364.00 |