α/β-SNAP Antibody (G-3): sc-48349

α/β-SNAP Antibody (G-3) is a mouse monoclonal IgG1 kappa light chain antibody that detects α/β-SNAP of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). α/β-SNAP (G-3) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. α/β-SNAP plays a crucial role in exocytosis, which is essential for neurotransmitter release and other cellular secretion mechanisms. α/β-SNAP functions as a soluble NSF attachment protein that facilitates SNARE complex assembly, a critical component in vesicle fusion with target membranes. This process maintains proper synaptic transmission and cellular communication, making α/β-SNAP essential in both neuronal and non-neuronal cells. α/β-SNAP interaction with syntaxins and VAMPs underscores α/β-SNAP significance in regulating membrane fusion events. By providing a reliable tool for studying exocytosis dynamics, anti-α/β-SNAP antibody (G-3) is invaluable for researchers investigating synaptic function and related disorders.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

α/β-SNAP Antibody (G-3) References:

1. Expression of neuroendocrine markers: a signature of human undifferentiated carcinoma of the colon and rectum.  |  Grabowski, P., et al. 2002. Virchows Arch. 441: 256-63. PMID: 12242522
2. Heterogeneous expression of neuroendocrine marker proteins in human undifferentiated carcinoma of the colon and rectum.  |  Grabowski, P., et al. 2004. Ann N Y Acad Sci. 1014: 270-4. PMID: 15153444
3. A ubiquitous membrane fusion protein alpha SNAP: a potential therapeutic target for cancer, diabetes and neurological disorders?  |  Andreeva, AV., et al. 2006. Expert Opin Ther Targets. 10: 723-33. PMID: 16981829
4. High affinity associations with α-SNAP enable calcium entry via Orai1 channels.  |  Ramanagoudr-Bhojappa, R., et al. 2021. PLoS One. 16: e0258670. PMID: 34653219
5. The syntaxin family of vesicular transport receptors.  |  Bennett, MK., et al. 1993. Cell. 74: 863-73. PMID: 7690687
6. Synaptobrevin binding to synaptophysin: a potential mechanism for controlling the exocytotic fusion machine.  |  Edelmann, L., et al. 1995. EMBO J. 14: 224-31. PMID: 7835333
7. Synaptic core complex of synaptobrevin, syntaxin, and SNAP25 forms high affinity alpha-SNAP binding site.  |  McMahon, HT. and Südhof, TC. 1995. J Biol Chem. 270: 2213-7. PMID: 7836452
8. Exocytosis relating proteins in the nervous system.  |  Yamaguchi, K. and Akagawa, K. 1994. Neurosci Res. 20: 289-92. PMID: 7870381
9. Synaptic vesicle membrane fusion complex: action of clostridial neurotoxins on assembly.  |  Hayashi, T., et al. 1994. EMBO J. 13: 5051-61. PMID: 7957071
10. A role for synaptotagmin (p65) in regulated exocytosis.  |  Elferink, LA., et al. 1993. Cell. 72: 153-9. PMID: 8422678
11. Stimulation of NSF ATPase activity by alpha-SNAP is required for SNARE complex disassembly and exocytosis.  |  Barnard, RJ., et al. 1997. J Cell Biol. 139: 875-83. PMID: 9362506
12. Structural organization of the synaptic exocytosis core complex.  |  Lin, RC. and Scheller, RH. 1997. Neuron. 19: 1087-94. PMID: 9390521

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-α/β-SNAP Antibody (G-3) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-α/β-SNAP Antibody (G-3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

α/β-SNAP Antibody (G-3) Specifications

Alternate Product Name: α/β-SNAP

Product Clone Name: G-3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-295

Epitope Target: α-SNAP

Epitope Species: human

Product Reactivity/Detection: α-SNAP and β-SNAP

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for α/β-SNAP Antibody (G-3): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin