α-Adaptin 1 Antibody (F-9): sc-398016
- α-Adaptin 1 Antibody (F-9) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 952-977 at the C-terminus of α-Adaptin 1 of mouse origin
- recommended for detection of α-Adaptin 1 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including and equine, canine, bovine and porcine
- See α-Adaptin 1/2 (C-8): sc-17771 for α-Adaptin 1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for α-Adaptin 1 Antibody (F-9) for WB and IHC(P) applications. These reagents are now offered in bundles with α-Adaptin 1 Antibody (F-9) (see ordering information below).
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α-Adaptin 1 Antibody (F-9) is a mouse monoclonal IgG1 antibody that detects α-Adaptin 1 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). α-Adaptin 1 plays a crucial role in clathrin-mediated endocytosis, which is essential for receptor internalization and membrane protein uptake, thereby regulating cellular signaling and nutrient uptake. α-Adaptin 1 is primarily located at the plasma membrane and in clathrin-coated pits, where α-Adaptin 1 interacts with other adaptin proteins to facilitate vesicle formation for cargo transport within cells. Proper functioning of α-Adaptin 1 maintains cellular homeostasis and ensures efficient cell-to-cell communication, making α-Adaptin 1 a key player in various physiological processes. α-Adaptin 1 undergoes post-translational modifications, such as phosphorylation, which can influence activity and protein interactions, further underscoring α-Adaptin 1′s importance in cellular dynamics. With broad species reactivity and versatility in multiple applications, anti-α-Adaptin 1 antibody (F-9) serves as an invaluable tool for researchers studying endocytic pathways and related cellular mechanisms.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
α-Adaptin 1 Antibody (F-9) References:
- The essential role of clathrin-mediated endocytosis in the infectious entry of human enterovirus 71. | Hussain, KM., et al. 2011. J Biol Chem. 286: 309-21. PMID: 20956521
- Identification of novel genes and networks governing hematopoietic stem cell development. | Han, T., et al. 2016. EMBO Rep. 17: 1814-1828. PMID: 27797851
- Molecular cloning of novel transcripts of the adaptor-related protein complex 2 alpha 1 subunit (AP2A1) gene, using Next-Generation Sequencing. | Adamopoulos, PG., et al. 2018. Gene. 678: 55-64. PMID: 30081190
- Flotillin and AP2A1/2 Promote IGF-1 Receptor Association with Clathrin and Internalization in Primary Human Keratinocytes. | Dam, DHM., et al. 2020. J Invest Dermatol. 140: 1743-1752.e4. PMID: 32027876
- Full-length IL-33 regulates Smad3 phosphorylation and gene transcription in a distinctive AP2-dependent manner. | Luzina, IG., et al. 2020. Cell Immunol. 357: 104203. PMID: 32977155
- Alpha adaptins show isoform-specific association with neurofibrillary tangles in Alzheimer's disease. | Srinivasan, S., et al. 2022. Neuropathol Appl Neurobiol. 48: e12776. PMID: 34820873
- AP2M1 mediates autophagy-induced CLDN2 (claudin 2) degradation through endocytosis and interaction with LC3 and reduces intestinal epithelial tight junction permeability. | Ganapathy, AS., et al. 2022. Autophagy. 18: 2086-2103. PMID: 34964704
- Adaptor protein complex 2 in the orbitofrontal cortex predicts alcohol use disorder. | Mulholland, PJ., et al. 2023. Mol Psychiatry. 28: 4766-4776. PMID: 37679472
- Autophagy-mediated NKG2D internalization impairs NK cell function and exacerbates radiation pneumonitis. | Wang, R., et al. 2023. Front Immunol. 14: 1250920. PMID: 38077388
- AP2A1 modulates cell states between senescence and rejuvenation. | Chantachotikul, P., et al. 2025. Cell Signal. 127: 111616. PMID: 39848456
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
α-Adaptin 1 Antibody (F-9) | sc-398016 | 200 µg/ml | $322.00 | |||
α-Adaptin 1 Antibody (F-9): m-IgG Fc BP-HRP Bundle | sc-538355 | 200 µg Ab; 10 µg BP | $361.00 | |||
α-Adaptin 1 Antibody (F-9): m-IgGκ BP-HRP Bundle | sc-535948 | 200 µg Ab; 40 µg BP | $361.00 | |||
α-Adaptin 1 Antibody (F-9): m-IgG1 BP-HRP Bundle | sc-545657 | 200 µg Ab; 20 µg BP | $361.00 | |||
α-Adaptin 1 (F-9) Neutralizing Peptide | sc-398016 P | 100 µg/0.5 ml | $69.00 |