α-actinin Antibody (B-12): sc-166524
- α-actinin Antibody (B-12) is a mouse monoclonal IgG2a κ, cited in 24 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 872-891 at the C-terminus of α-actinin of human origin
- recommended for detection of α-actinin-1, α-actinin-2 and α-actinin-4 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- See α-actinin (H-2): sc-17829 for α-actinin antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgG2a BP-HRP are the preferred secondary detection reagents for α-actinin Antibody (B-12) for WB and IHC(P) applications. These reagents are now offered in bundles with α-actinin Antibody (B-12) (see ordering information below).
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α-actinin Antibody (B-12) is a mouse monoclonal IgG2a antibody that detects α-actinin in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). α-actinin is a crucial cytoskeletal protein that plays a significant role in maintaining cellular structural integrity by cross-linking actin filaments, thereby forming a stable network that supports cellular shape and function. α-actinin is predominantly located in the cytoskeleton of muscle and non-muscle cells, including skeletal, cardiac, and smooth muscle cells, where α-actinin is essential for muscle contraction and cellular signaling. Proper localization of α-actinin is vital for muscle function and cellular organization, as α-actinin anchors actin filaments to various intracellular structures, facilitating the transmission of mechanical forces and signals within the cell. Mutations in the gene encoding α-actinin-4 have been linked to focal segmental glomerulosclerosis 1 (FSGS1), a serious renal condition that can lead to progressive kidney dysfunction and failure, highlighting α-actinin′s critical role in both muscle and kidney health. anti-α-actinin antibody (B-12) serves as an invaluable tool for researchers studying cytoskeletal organization and related pathologies.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
α-actinin Antibody (B-12) | sc-166524 | 200 µg/ml | $322.00 | |||
α-actinin Antibody (B-12): m-IgG Fc BP-HRP Bundle | sc-540116 | 200 µg Ab; 10 µg BP | $361.00 | |||
α-actinin Antibody (B-12): m-IgG2a BP-HRP Bundle | sc-546854 | 200 µg Ab; 10 µg BP | $361.00 | |||
α-actinin (B-12) Neutralizing Peptide | sc-166524 P | 100 µg/0.5 ml | $69.00 |