α-actinin-4 Antibody (B-11): sc-390180

α-actinin-4 Antibody (B-11) is a mouse monoclonal IgG2a antibody that detects α-actinin-4 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). α-actinin-4 is a crucial cytoskeletal protein that plays a significant role in maintaining cellular structural integrity by cross-linking actin filaments, which is essential for cellular shape and motility. α-actinin-4 is predominantly located in the cytoskeleton of muscle and non-muscle cells, including skeletal, cardiac, and smooth muscle cells, where anti-α-actinin-4 antibody (B-11) contributes to studying the organization of the actin cytoskeleton. Proper localization and function of α-actinin-4 are vital for various cellular processes, including muscle contraction and cell signaling. Mutations in the gene encoding α-actinin-4 have been linked to focal segmental glomerulosclerosis 1 (FSGS1), a serious renal condition characterized by progressive kidney dysfunction and potential renal failure. α-actinin-4 (B-11) antibody serves as an invaluable tool for researchers studying cytoskeletal dynamics and implications in health and disease.

The preferred α-actinin antibody is α-actinin Antibody (H-2): sc-17829.