ALK-1 Antibody (RM0015-1B03): sc-101556

ALK-1 Antibody (RM0015-1B03) is a rat monoclonal IgG2 antibody that detects ALK-1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). ALK-1 (RM0015-1B03) antibody is available as a non-conjugated anti-ALK-1 antibody, crucial for studying hereditary hemorrhagic telangiectasia (HHT), an autosomal dominant disorder characterized by vascular abnormalities such as dilated vessels, hemorrhages, and ischemic events in vital organs. ALK-1, also known as activin receptor-like kinase 1, plays a significant role in the TGFβ signaling pathway, which is essential for vascular development and homeostasis. Mutations in ALK-1 are linked to HHT2, leading to haploinsufficiency that disrupts normal endothelial function and contributes to the disease′s vascular malformations. ALK-1 is primarily expressed in vascular endothelial cells and preferentially binds to TGFβ1, highlighting ALK-1′s importance in mediating cellular responses to this growth factor. Understanding ALK-1 function and interactions within the TGFβ superfamily is vital for developing targeted therapies for conditions associated with vascular dysregulation.

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ALK-1 Antibody (RM0015-1B03) References:

1. Novel missense and frameshift mutations in the activin receptor-like kinase-1 gene in hereditary hemorrhagic telangiectasia. Mutations in brief no. 164. Online.  |  Klaus, DJ., et al. 1998. Hum Mutat. 12: 137. PMID: 10694922
2. Endoglin-deficient mice, a unique model to study hereditary hemorrhagic telangiectasia.  |  Bourdeau, A., et al. 2000. Trends Cardiovasc Med. 10: 279-85. PMID: 11343967
3. Potential role of modifier genes influencing transforming growth factor-beta1 levels in the development of vascular defects in endoglin heterozygous mice with hereditary hemorrhagic telangiectasia.  |  Bourdeau, A., et al. 2001. Am J Pathol. 158: 2011-20. PMID: 11395379
4. Regulation of the ALK1 ligands, BMP9 and BMP10.  |  Li, W., et al. 2016. Biochem Soc Trans. 44: 1135-41. PMID: 27528761
5. Targeting tumour vasculature by inhibiting activin receptor-like kinase (ALK)1 function.  |  de Vinuesa, AG., et al. 2016. Biochem Soc Trans. 44: 1142-9. PMID: 27528762
6. Endoglin and alk1 as therapeutic targets for hereditary hemorrhagic telangiectasia.  |  Ruiz-Llorente, L., et al. 2017. Expert Opin Ther Targets. 21: 933-947. PMID: 28796572
7. ALK1 controls hepatic vessel formation, angiodiversity, and angiocrine functions in hereditary hemorrhagic telangiectasia of the liver.  |  Schmid, CD., et al. 2023. Hepatology. 77: 1211-1227. PMID: 35776660
8. Impact of heterozygous ALK1 mutations on the transcriptomic response to BMP9 and BMP10 in endothelial cells from hereditary hemorrhagic telangiectasia and pulmonary arterial hypertension donors.  |  Al Tabosh, T., et al. 2024. Angiogenesis. 27: 211-227. PMID: 38294582
9. Blood flow regulates acvrl1 transcription via ligand-dependent Alk1 activity.  |  Anzell, AR., et al. 2024. Angiogenesis. 27: 501-522. PMID: 38727966
10. Cloning and characterization of the murine activin receptor like kinase-1 (ALK-1) homolog.  |  Wu, X., et al. 1995. Biochem Biophys Res Commun. 216: 78-83. PMID: 7488127
11. Expression and structural features of endoglin (CD105), a transforming growth factor beta1 and beta3 binding protein, in human melanoma.  |  Altomonte, M., et al. 1996. Br J Cancer. 74: 1586-91. PMID: 8932339
12. Mutation and expression analysis of the endoglin gene in hereditary hemorrhagic telangiectasia reveals null alleles.  |  Gallione, CJ., et al. 1998. Hum Mutat. 11: 286-94. PMID: 9554745

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-ALK-1 Antibody (RM0015-1B03) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-ALK-1 Antibody (RM0015-1B03) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

ALK-1 Antibody (RM0015-1B03) Specifications

Alternate Product Name: ALK-1

Product Clone Name: RM0015-1B03

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₂

Amino Acids:

Epitope Target: ALK-1

Epitope Species: mouse

Product Reactivity/Detection: ALK-1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF

Vialing Information: Each vial contains 100 µg IgG₂ in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for ALK-1 Antibody (RM0015-1B03): N/A

The preferred ALK-1 antibody is ALK-1 Antibody (F-1): sc-518148.