Aldolase C Antibody (H-11): sc-271593

Aldolase C Antibody (H-11) is a mouse monoclonal IgG1 kappa light chain antibody that detects Aldolase C protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-Aldolase C antibody (H-11) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Aldolase C, also known as fructose-bisphosphate aldolase C, catalyzes the reversible condensation of glycerone phosphate and glyceraldehyde 3-phosphate into fructose 1,6-bisphosphate during glycolysis, serving as a key intermediate in energy metabolism. Aldolase C is predominantly expressed in Purkinje cells of the cerebellum, maintaining the metabolic demands of these neurons crucial for motor coordination and balance. Anti-Aldolase C antibody (H-11) helps reveal unique expression patterns in Purkinje cells, organized into distinct bands alternating with Aldolase C-negative cells, highlighting specialized roles in neuronal metabolism. Understanding Aldolase C function and localization provides valuable insights into neurological disorders and potential therapeutic approaches.

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Aldolase C Antibody (H-11) References:

1. Exploring substrate binding and discrimination in fructose1, 6-bisphosphate and tagatose 1,6-bisphosphate aldolases.  |  Zgiby, SM., et al. 2000. Eur J Biochem. 267: 1858-68. PMID: 10712619
2. Characterization of the responsive elements to hormones in the rat aldolase B gene.  |  Takano, Y., et al. 2000. Arch Biochem Biophys. 377: 58-64. PMID: 10775441
3. The complete amino acid sequence of human skeletal-muscle fructose-bisphosphate aldolase.  |  Freemont, PS., et al. 1988. Biochem J. 249: 779-88. PMID: 3355497
4. Human aldolase A gene. Structural organization and tissue-specific expression by multiple promoters and alternate mRNA processing.  |  Izzo, P., et al. 1988. Eur J Biochem. 174: 569-78. PMID: 3391172
5. Isoquercitrin Upregulates Aldolase C Through Nrf2 to Ameliorate OGD/R-Induced Damage in SH-SY5Y Cells.  |  Cai, SC., et al. 2021. Neurotox Res. 39: 1959-1969. PMID: 34773594
6. Aldolase C in brain tumour.  |  Sugimura, T., et al. 1969. Nature. 222: 1070. PMID: 4306797
7. Distribution of Purkinje cell-specific Zebrin-II/aldolase C immunoreactivity in the mouse, rat, rabbit, and human retina.  |  Caffé, AR., et al. 1994. J Comp Neurol. 348: 291-7. PMID: 7814693
8. Aldolase C/zebrin II and the regionalization of the cerebellum.  |  Hawkes, R. and Herrup, K. 1995. J Mol Neurosci. 6: 147-58. PMID: 8672398
9. A search for primitive Purkinje cells: zebrin II expression in sea lampreys (Petromyzon marinus).  |  Lannoo, MJ. and Hawkes, R. 1997. Neurosci Lett. 237: 53-5. PMID: 9406878
10. Genomic sequences of aldolase C (Zebrin II) direct lacZ expression exclusively in non-neuronal cells of transgenic mice.  |  Walther, EU., et al. 1998. Proc Natl Acad Sci U S A. 95: 2615-20. PMID: 9482935
11. The glutamate transporter EAAT4 in rat cerebellar Purkinje cells: a glutamate-gated chloride channel concentrated near the synapse in parts of the dendritic membrane facing astroglia.  |  Dehnes, Y., et al. 1998. J Neurosci. 18: 3606-19. PMID: 9570792
12. Regionalization defects in the weaver mouse cerebellum.  |  Eisenman, LM., et al. 1998. J Comp Neurol. 394: 431-44. PMID: 9590553

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Aldolase C Antibody (H-11) has 12 citations in a variety of scientific publications.

Primary antibodies like Anti-Aldolase C Antibody (H-11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Aldolase C Antibody (H-11) Specifications

Alternate Product Name: Aldolase C

Product Clone Name: H-11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 77-112

Epitope Target: Aldolase C

Epitope Species: human

Product Reactivity/Detection: Aldolase C

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: equine, canine, bovine and porcine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 12 citations in various scientific publications

Available Conjugates/Forms for Aldolase C Antibody (H-11): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin