Aldolase B Antibody (19): sc-130303
- Aldolase B Antibody (19) is a mouse monoclonal IgG2a κ, cited in 1 publications, provided at 200 µg/ml
- raised against recombinant Aldolase B of human origin
- recommended for detection of Aldolase B of mouse, rat and human origin by WB, IP and ELISA
- m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Aldolase B Antibody (19) for WB applications. These reagents are now offered in bundles with Aldolase B Antibody (19) (see ordering information below).
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Aldolase B Antibody (19) is a mouse monoclonal IgG2a light chain antibody that detects Aldolase B in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Aldolase B plays a crucial role in carbohydrate metabolism by catalyzing the reversible conversion of fructose 1,6-bisphosphate into glycerone phosphate and glyceraldehyde 3-phosphate, which are essential intermediates in the glycolytic pathway. This enzyme is particularly important in the liver, where Aldolase B helps regulate blood sugar levels and is influenced by hormonal signals such as insulin and glucagon. Dysregulation of Aldolase B can lead to metabolic disorders, including hereditary fructose intolerance, highlighting its significance in maintaining metabolic homeostasis. Anti-Aldolase B antibody (19) provides reliable detection and quantification of this vital enzyme, facilitating research into its role in various physiological and pathological processes.
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Aldolase B Antibody (19) References:
- Different involvement for aldolase isoenzymes in kidney glucose metabolism: aldolase B but not aldolase A colocalizes and forms a complex with FBPase. | Yañez, AJ., et al. 2005. J Cell Physiol. 202: 743-53. PMID: 15389646
- Aldolase B-Mediated Fructose Metabolism Drives Metabolic Reprogramming of Colon Cancer Liver Metastasis. | Bu, P., et al. 2018. Cell Metab. 27: 1249-1262.e4. PMID: 29706565
- Patients With Aldolase B Deficiency Are Characterized by Increased Intrahepatic Triglyceride Content. | Simons, N., et al. 2019. J Clin Endocrinol Metab. 104: 5056-5064. PMID: 30901028
- Aldolase B impairs DNA mismatch repair and induces apoptosis in colon adenocarcinoma. | Lian, J., et al. 2019. Pathol Res Pract. 215: 152597. PMID: 31564566
- Fructose-1,6-Bisphosphate Aldolase B Depletion Promotes Hepatocellular Carcinogenesis Through Activating Insulin Receptor Signaling and Lipogenesis. | Liu, G., et al. 2021. Hepatology. 74: 3037-3055. PMID: 34292642
- Aldolase B suppresses hepatocellular carcinogenesis by inhibiting G6PD and pentose phosphate pathways. | Li, M., et al. 2020. Nat Cancer. 1: 735-747. PMID: 35122041
- Aldolase B attenuates clear cell renal cell carcinoma progression by inhibiting CtBP2. | Tan, M., et al. 2023. Front Med. 17: 503-517. PMID: 36790589
- The Network Basis for the Structural Thermostability and the Functional Thermoactivity of Aldolase B. | Wang, G. 2023. Molecules. 28: PMID: 36838836
- Pan-cancer analysis of aldolase B gene as a novel prognostic biomarker for human cancers. | Zhao, N. and Xu, H. 2023. Medicine (Baltimore). 102: e33577. PMID: 37083815
- Aldolase B-driven lactagenesis and CEACAM6 activation promote cell renewal and chemoresistance in colorectal cancer through the Warburg effect. | Chu, YD., et al. 2023. Cell Death Dis. 14: 660. PMID: 37816733
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Aldolase B Antibody (19) | sc-130303 | 200 µg/ml | $322.00 | |||
Aldolase B Antibody (19): m-IgGκ BP-HRP Bundle | sc-534554 | 200 µg Ab; 40 µg BP | $361.00 | |||
Aldolase B Antibody (19): m-IgG2a BP-HRP Bundle | sc-546193 | 200 µg Ab; 10 µg BP | $361.00 |