Aldolase A Antibody (1F8): sc-53933
- Aldolase A Antibody (1F8) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against full length Aldolase A of human origin
- recommended for detection of Aldolase A of mouse, rat and human origin by WB, IP and ELISA
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Aldolase A Antibody (1F8) for WB applications. These reagents are now offered in bundles with Aldolase A Antibody (1F8) (see ordering information below).
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Aldolase A Antibody (1F8) is a mouse monoclonal IgG1 antibody that detects Aldolase A in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Aldolase A plays a crucial role in glycolysis, catalyzing the reversible condensation of glycerone phosphate and glyceraldehyde 3-phosphate into fructose 1,6-bisphosphate, a key intermediate in energy metabolism. This enzyme helps regulate carbon flow through the glycolytic pathway, which is essential for cellular energy production. Aldolase A is one of the most highly conserved enzymes, with only about 2% of its residues changing over 100 million years, highlighting its fundamental role in cellular metabolism. Anti-Aldolase A antibody (1F8) enables researchers to study expression and function in various physiological and pathological contexts, including potential implications in metabolic disorders. Aldolase A monoclonal antibody (1F8) serves as an invaluable tool for scientists investigating the intricacies of energy metabolism and its regulation in different tissues.
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Aldolase A Antibody (1F8) References:
- A thermolabile aldolase A mutant causes fever-induced recurrent rhabdomyolysis without hemolytic anemia. | Mamoune, A., et al. 2014. PLoS Genet. 10: e1004711. PMID: 25392908
- 2-Deoxyribose-5-phosphate aldolase, a remarkably tolerant aldolase towards nucleophile substrates. | Chambre, D., et al. 2019. Chem Commun (Camb). 55: 7498-7501. PMID: 31187106
- A Robust and Cost-Effective Luminescent-Based High-Throughput Assay for Fructose-1,6-Bisphosphate Aldolase A. | Cho, EJ., et al. 2020. SLAS Discov. 25: 1038-1046. PMID: 32462959
- Loss-of-Function Genetic Screening Identifies Aldolase A as an Essential Driver for Liver Cancer Cell Growth Under Hypoxia. | Niu, Y., et al. 2021. Hepatology. 74: 1461-1479. PMID: 33813748
- Substitutions at a rheostat position in human aldolase A cause a shift in the conformational population. | Fenton, KD., et al. 2022. Protein Sci. 31: 357-370. PMID: 34734672
- LOXL2-dependent deacetylation of aldolase A induces metabolic reprogramming and tumor progression. | Jiao, JW., et al. 2022. Redox Biol. 57: 102496. PMID: 36209516
- Aldolase A Accelerates Cancer Progression by Modulating mRNA Translation and Protein Biosynthesis via Noncanonical Mechanisms. | Song, J., et al. 2023. Adv Sci (Weinh). 10: e2302425. PMID: 37431681
- Aldolase A promotes cervical cancer cell radioresistance by regulating the glycolysis and DNA damage after irradiation. | Zhou, J., et al. 2023. Cancer Biol Ther. 24: 2287128. PMID: 38010897
- A pro-metastatic tRNA fragment drives aldolase A oligomerization to enhance aerobic glycolysis in lung adenocarcinoma. | Wang, Q., et al. 2024. Cell Rep. 43: 114550. PMID: 39058593
- Beyond Glycolysis: Aldolase A Is a Novel Effector in Reelin-Mediated Dendritic Development. | Lagani, GD., et al. 2024. J Neurosci. 44: PMID: 39227156
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Aldolase A Antibody (1F8) | sc-53933 | 200 µg/ml | $322.00 | |||
Aldolase A Antibody (1F8): m-IgG Fc BP-HRP Bundle | sc-537015 | 200 µg Ab; 10 µg BP | $361.00 | |||
Aldolase A Antibody (1F8): m-IgGκ BP-HRP Bundle | sc-534196 | 200 µg Ab; 40 µg BP | $361.00 | |||
Aldolase A Antibody (1F8): m-IgG1 BP-HRP Bundle | sc-544957 | 200 µg Ab; 20 µg BP | $361.00 |