Aldehyde dehydrogenase 6-A1/ALDH6A1 Antibody (C-9): sc-271582

ALDH6A1 Antibody (C-9) is a mouse monoclonal IgG1 kappa light chain antibody that detects ALDH6A1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). ALDH6A1 (C-9) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. ALDH6A1, also known as aldehyde dehydrogenase family 6 member A1, is a crucial mitochondrial enzyme that plays a significant role in the metabolism of various substrates, including malonate and methylmalonate semialdehydes, converting them into acetyl-CoA and propionyl-CoA. This enzymatic activity is vital for the catabolism of valine and pyrimidines, which are essential for energy production and the synthesis of nucleotides, respectively. Proper functioning of ALDH6A1 is important for maintaining metabolic homeostasis and preventing the accumulation of toxic aldehyde intermediates, which can lead to cellular damage and contribute to various metabolic disorders. Anti-ALDH6A1 antibody (C-9) enables researchers to gain insights into the role of this enzyme in metabolic pathways and its implications in health and disease.

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Aldehyde dehydrogenase 6-A1/ALDH6A1 Antibody (C-9) References:

1. Polymorphisms of human aldehyde dehydrogenases. Consequences for drug metabolism and disease.  |  Vasiliou, V. and Pappa, A. 2000. Pharmacology. 61: 192-8. PMID: 10971205
2. Mammalian methylmalonate-semialdehyde dehydrogenase.  |  Kedishvili, NY., et al. 2000. Methods Enzymol. 324: 207-18. PMID: 10989432
3. Proteome approach to characterize the methylmalonate-semialdehyde dehydrogenase that is regulated by gibberellin.  |  Tanaka, N., et al. 2005. J Proteome Res. 4: 1575-82. PMID: 16212409
4. Mechanistic characterization of the MSDH (methylmalonate semialdehyde dehydrogenase) from Bacillus subtilis.  |  Stines-Chaumeil, C., et al. 2006. Biochem J. 395: 107-15. PMID: 16332250
5. Identification of differential expression of genes in hepatocellular carcinoma by suppression subtractive hybridization combined cDNA microarray.  |  Liu, Y., et al. 2007. Oncol Rep. 18: 943-51. PMID: 17786358
6. HNF4 alpha orchestrates a set of 14 genes to down-regulate cell proliferation in kidney cells.  |  Grigo, K., et al. 2008. Biol Chem. 389: 179-87. PMID: 18163890
7. Purification and characterization of methylmalonate-semialdehyde dehydrogenase from rat liver. Identity to malonate-semialdehyde dehydrogenase.  |  Goodwin, GW., et al. 1989. J Biol Chem. 264: 14965-71. PMID: 2768248
8. Regulation of enzymatic activity by active site fatty acylation. A new role for long chain fatty acid acylation of proteins.  |  Berthiaume, L., et al. 1994. J Biol Chem. 269: 6498-505. PMID: 8120000
9. Novel use of an iodo-myristyl-CoA analog identifies a semialdehyde dehydrogenase in bovine liver.  |  Deichaite, I., et al. 1993. J Biol Chem. 268: 13738-47. PMID: 8514806

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Aldehyde dehydrogenase 6-A1/ALDH6A1 Antibody (C-9) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-Aldehyde dehydrogenase 6-A1/ALDH6A1 Antibody (C-9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Aldehyde dehydrogenase 6-A1/ALDH6A1 Antibody (C-9) Specifications

Alternate Product Name: ALDH6A1

Product Clone Name: C-9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 49-75

Epitope Target: ALDH6A1

Epitope Species: human

Product Reactivity/Detection: ALDH6A1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: canine, bovine and porcine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for Aldehyde dehydrogenase 6-A1/ALDH6A1 Antibody (C-9): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin