Aldehyde dehydrogenase 4-A1/P5CDH/ALDH4A1 Antibody (H-6): sc-398894
- Aldehyde dehydrogenase 4-A1/P5CDH/ALDH4A1 Antibody (H-6) is a mouse monoclonal IgG3 κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 264-287 within an internal region of ALDH4A1 of human origin
- recommended for detection of ALDH4A1 of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG3 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Aldehyde dehydrogenase 4-A1/P5CDH/ALDH4A1 Antibody (H-6) for WB applications. These reagents are now offered in bundles with Aldehyde dehydrogenase 4-A1/P5CDH/ALDH4A1 Antibody (H-6) (see ordering information below).
ALDH4A1 Antibody (H-6) is a mouse monoclonal IgG3 antibody that detects ALDH4A1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ALDH4A1, also known as P5CD (Delta-1-pyrroline-5-carboxylate dehydrogenase), plays a crucial role in the proline degradation pathway by catalyzing the conversion of Delta-1-pyrroline-5-carboxylate (P5C) to glutamate within the mitochondrial matrix. This enzymatic activity is vital for maintaining cellular homeostasis and regulating proline levels, which are essential for various metabolic processes, including the synthesis of neurotransmitters and the detoxification of harmful aldehydes. Dysregulation of ALDH4A1 due to genetic mutations can lead to hyperprolinemia type II, a condition marked by elevated levels of proline and P5C, which can result in severe neurological impairments such as mental retardation and seizures. Anti-ALDH4A1 antibody (H-6) is an invaluable tool for researchers studying the implications of ALDH4A1 in metabolic disorders and its potential as a therapeutic target.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Aldehyde dehydrogenase 4-A1/P5CDH/ALDH4A1 Antibody (H-6) | sc-398894 | 200 µg/ml | $322.00 | |||
Aldehyde dehydrogenase 4-A1/P5CDH/ALDH4A1 Antibody (H-6): m-IgGκ BP-HRP Bundle | sc-536173 | 200 µg Ab; 40 µg BP | $361.00 | |||
Aldehyde dehydrogenase 4-A1/P5CDH/ALDH4A1 Antibody (H-6): m-IgG3 BP-HRP Bundle | sc-550317 | 200 µg Ab; 40 µg BP | $361.00 | |||
Aldehyde dehydrogenase 4-A1/P5CDH/ALDH4A1 (H-6) Neutralizing Peptide | sc-398894 P | 100 µg/0.5 ml | $69.00 |