Aldehyde dehydrogenase 3-A2/ALDH3A2 Antibody (G-9): sc-373921

ALDH3A2 Antibody (G-9) is a mouse monoclonal IgG1 kappa light chain antibody that detects ALDH3A2 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-ALDH3A2 antibody (G-9) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. ALDH3A2, also known as aldehyde dehydrogenase 3 family, member A2, plays a crucial role in the detoxification of harmful aldehydes, particularly alcohol-derived acetaldehyde, by catalyzing the NAD+-dependent oxidation of long-chain aliphatic aldehydes into fatty acids. This enzymatic activity is vital for maintaining cellular health and lipid metabolism, as ALDH3A2 helps prevent the accumulation of toxic aldehydes that can lead to cellular damage. ALDH3A2 is a 485 amino acid single-pass membrane protein predominantly localized to the cytoplasmic side of the endoplasmic reticulum and expressed in various tissues, including the liver, heart, lung, brain, kidney, and placenta. Defects in the gene encoding ALDH3A2 are associated with Sjögren-Larsson syndrome, a serious autosomal recessive neurocutaneous disorder characterized by severe mental retardation, seizures, and speech defects. Multiple isoforms of ALDH3A2 arise from alternative splicing events, which may contribute to diverse functional roles in different tissues.

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Aldehyde dehydrogenase 3-A2/ALDH3A2 Antibody (G-9) References:

1. Sjögren-Larsson syndrome: molecular genetics and biochemical pathogenesis of fatty aldehyde dehydrogenase deficiency.  |  Rizzo, WB. 2007. Mol Genet Metab. 90: 1-9. PMID: 16996289
2. Dual subcellular localization in the endoplasmic reticulum and peroxisomes and a vital role in protecting against oxidative stress of fatty aldehyde dehydrogenase are achieved by alternative splicing.  |  Ashibe, B., et al. 2007. J Biol Chem. 282: 20763-73. PMID: 17510064
3. Novel and recurrent ALDH3A2 mutations in Italian patients with Sjögren-Larsson syndrome.  |  Didona, B., et al. 2007. J Hum Genet. 52: 865-870. PMID: 17902024
4. Abnormal fatty alcohol metabolism in cultured keratinocytes from patients with Sjögren-Larsson syndrome.  |  Rizzo, WB., et al. 2008. J Lipid Res. 49: 410-9. PMID: 17971613
5. Sjögren-larsson syndrome and crystalline maculopathy associated with a novel mutation.  |  Jean-François, E., et al. 2007. Arch Ophthalmol. 125: 1582-3. PMID: 17998529
6. Characterisation of recombinant human fatty aldehyde dehydrogenase: implications for Sjögren-Larsson syndrome.  |  Lloyd, MD., et al. 2007. J Enzyme Inhib Med Chem. 22: 584-90. PMID: 18035827
7. Sjögren-Larsson syndrome is caused by mutations in the fatty aldehyde dehydrogenase gene.  |  De Laurenzi, V., et al. 1996. Nat Genet. 12: 52-7. PMID: 8528251
8. Genomic organization and expression of the human fatty aldehyde dehydrogenase gene (FALDH).  |  Rogers, GR., et al. 1997. Genomics. 39: 127-35. PMID: 9027499
9. Human fatty aldehyde dehydrogenase gene (ALDH10): organization and tissue-dependent expression.  |  Chang, C. and Yoshida, A. 1997. Genomics. 40: 80-5. PMID: 9070922

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Aldehyde dehydrogenase 3-A2/ALDH3A2 Antibody (G-9) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-Aldehyde dehydrogenase 3-A2/ALDH3A2 Antibody (G-9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Aldehyde dehydrogenase 3-A2/ALDH3A2 Antibody (G-9) Specifications

Alternate Product Name: ALDH3A2

Product Clone Name: G-9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 28-103

Epitope Target: ALDH3A2

Epitope Species: human

Product Reactivity/Detection: ALDH3A2

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Aldehyde dehydrogenase 3-A2/ALDH3A2 Antibody (G-9): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin