Aldehyde dehydrogenase 3-A1/ALDH3A1 Antibody (E-11): sc-514043

ALDH3A1 Antibody (E-11) is a mouse monoclonal IgG1 antibody that detects aldehyde dehydrogenase 3A1 (ALDH3A1) in mouse and rat samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ALDH3A1 plays a crucial role in the metabolism of aldehydes, particularly in the detoxification of harmful compounds, which is vital for cellular health and protection against oxidative stress. ALDH3A1 is predominantly located in the cytoplasm, where ALDH3A1 forms a homodimer that preferentially oxidizes aromatic aldehyde substrates, thereby contributing to the cellular defense mechanism against oxidative damage. ALDH3A1 is particularly significant in tissues such as the stomach, where ALDH3A1 helps to metabolize potentially toxic aldehydes generated during digestion. Additionally, ALDH3A1 is known to be upregulated in certain tumors, indicating ALDH3A1′s involvement in cancer metabolism and the potential for therapeutic targeting. With ALDH3A1′s ability to interact with various substrates and importance in detoxification pathways, ALDH3A1 is a key player in maintaining cellular homeostasis and mitigating the effects of oxidative stress.

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Aldehyde dehydrogenase 3-A1/ALDH3A1 Antibody (E-11) References:

1. Inhibition of ALDH3A1-catalyzed oxidation by chlorpropamide analogues.  |  Sládek, NE., et al. 2001. Chem Biol Interact. 138: 201-15. PMID: 11672702
2. Cellular levels of aldehyde dehydrogenases (ALDH1A1 and ALDH3A1) as predictors of therapeutic responses to cyclophosphamide-based chemotherapy of breast cancer: a retrospective study. Rational individualization of oxazaphosphorine-based cancer chemotherapeutic regimens.  |  Sládek, NE., et al. 2002. Cancer Chemother Pharmacol. 49: 309-21. PMID: 11914911
3. Salivary aldehyde dehydrogenase: activity towards aromatic aldehydes and comparison with recombinant ALDH3A1.  |  Giebułtowicz, J., et al. 2009. Molecules. 14: 2363-72. PMID: 19633610
4. Structural and functional modifications of corneal crystallin ALDH3A1 by UVB light.  |  Estey, T., et al. 2010. PLoS One. 5: e15218. PMID: 21203538
5. Pharmacological recruitment of aldehyde dehydrogenase 3A1 (ALDH3A1) to assist ALDH2 in acetaldehyde and ethanol metabolism in vivo.  |  Chen, CH., et al. 2015. Proc Natl Acad Sci U S A. 112: 3074-9. PMID: 25713355
6. Development of Highly Selective Fluorescent Probe Enabling Flow-Cytometric Isolation of ALDH3A1-Positive Viable Cells.  |  Yagishita, A., et al. 2017. Bioconjug Chem. 28: 302-306. PMID: 27976863
7. Synthetic lethality of the ALDH3A1 inhibitor dyclonine and xCT inhibitors in glutathione deficiency-resistant cancer cells.  |  Okazaki, S., et al. 2018. Oncotarget. 9: 33832-33843. PMID: 30333913
8. Mutation of the gene encoding the circadian clock component PERIOD2 in oncogenic cells confers chemoresistance by up-regulating the Aldh3a1 gene.  |  Katamune, C., et al. 2019. J Biol Chem. 294: 547-558. PMID: 30429219
9. Exosomes carrying ALDOA and ALDH3A1 from irradiated lung cancer cells enhance migration and invasion of recipients by accelerating glycolysis.  |  Wang, C., et al. 2020. Mol Cell Biochem. 469: 77-87. PMID: 32297178
10. Targeting aldehyde dehydrogenase ALDH3A1 increases ferroptosis vulnerability in squamous cancer.  |  Kong, S., et al. 2025. Oncogene.. PMID: 39863749

The preferred Aldehyde dehydrogenase 3-A1/ALDH3A1 antibody is Aldehyde dehydrogenase 3-A1/ALDH3A1 Antibody (G-2): sc-376089.