AKR1B10 Antibody (F-4): sc-365689
- AKR1B10 Antibody (F-4) is a mouse monoclonal IgG2b κ AKR1B10 antibody, cited in 3 publications, provided at 200 µg/ml
- raised against amino acids 79-147 mapping within an internal region of AKR1B10 of human origin
- AKR1B10 Antibody (F-4) is recommended for detection of AKR1B10 of human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-AKR1B10 Antibody (F-4) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for AKR1B10 Antibody (F-4) for WB and IHC(P) applications. These reagents are now offered in bundles with AKR1B10 Antibody (F-4) (see ordering information below).
AKR1B10 Antibody (F-4) is a mouse monoclonal IgG2b kappa light chain antibody that detects AKR1B10 of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). AKR1B10 (F-4) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. AKR1B10, also known as aldo-keto reductase family 1 member B10, aldose reductase-like-1, small intestine reductase, or aldose reductase-related protein, is predominantly expressed in the small intestine, colon, and adrenal gland, where AKR1B10 plays a crucial role in carbohydrate metabolism and detoxification processes. AKR1B10 functions as an efficient reductase for both aliphatic and aromatic aldehydes, maintaining cellular homeostasis and protecting tissues from carbonyl stress. AKR1B10 is involved in steroid metabolism and may influence the retinal-retinoic acid signaling pathway, highlighting AKR1B10′s importance in various physiological processes. AKR1B10 shows overexpression in non-small cell lung carcinoma and adenocarcinoma, with cigarette smoking identified as a significant contributing factor. AKR1B10′s ability to regulate cell proliferation and respond to oxidative stress underscores AKR1B10′s potential as a therapeutic target in cancer and metabolic disorders.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
AKR1B10 Antibody (F-4) References:
- AKR1B10: a new diagnostic marker of non-small cell lung carcinoma in smokers. | Penning, TM. 2005. Clin Cancer Res. 11: 1687-90. PMID: 15755988
- Overexpression of the aldo-keto reductase family protein AKR1B10 is highly correlated with smokers' non-small cell lung carcinomas. | Fukumoto, S., et al. 2005. Clin Cancer Res. 11: 1776-85. PMID: 15755999
- The association of aldose reductase gene (AKR1B1) polymorphisms with diabetic neuropathy in adolescents. | Donaghue, KC., et al. 2005. Diabet Med. 22: 1315-20. PMID: 16176189
- Purification and characterization of akr1b10 from human liver: role in carbonyl reduction of xenobiotics. | Martin, HJ., et al. 2006. Drug Metab Dispos. 34: 464-70. PMID: 16381663
- Comparative functional analysis of human medium-chain dehydrogenases, short-chain dehydrogenases/reductases and aldo-keto reductases with retinoids. | Gallego, O., et al. 2006. Biochem J. 399: 101-9. PMID: 16787387
- [Transcription TIMP3, DAPk1 and AKR1B10 genes in squamous cell lung cancer]. | Mashkova, TD., et al. 2006. Mol Biol (Mosk). 40: 1047-54. PMID: 17209433
- Reduced 293T cell susceptibility to acrolein due to aldose reductase-like-1 protein expression. | Zu, X., et al. 2007. Toxicol Sci. 97: 562-8. PMID: 17329238
- Aldo-keto reductase family 1, member B10 in uterine carcinomas: a potential risk factor of recurrence after surgical therapy in cervical cancer. | Yoshitake, H., et al. 2007. Int J Gynecol Cancer. 17: 1300-6. PMID: 17425679
- Aldo-keto reductase family 1 B10 gene silencing results in growth inhibition of colorectal cancer cells: Implication for cancer intervention. | Yan, R., et al. 2007. Int J Cancer. 121: 2301-6. PMID: 17597105
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
AKR1B10 Antibody (F-4) | sc-365689 | 200 µg/ml | $322.00 | |||
AKR1B10 Antibody (F-4): m-IgGκ BP-HRP Bundle | sc-522331 | 200 µg Ab, 40 µg BP | $361.00 | |||
AKR1B10 Antibody (F-4): m-IgG2b BP-HRP Bundle | sc-549022 | 200 µg Ab; 10 µg BP | $361.00 | |||
AKR1B10 Antibody (F-4) AC | sc-365689 AC | 500 µg/ml, 25% agarose | $424.00 | |||
AKR1B10 Antibody (F-4) HRP | sc-365689 HRP | 200 µg/ml | $322.00 | |||
AKR1B10 Antibody (F-4) FITC | sc-365689 FITC | 200 µg/ml | $336.00 | |||
AKR1B10 Antibody (F-4) PE | sc-365689 PE | 200 µg/ml | $349.00 | |||
AKR1B10 Antibody (F-4) Alexa Fluor® 488 | sc-365689 AF488 | 200 µg/ml | $364.00 | |||
AKR1B10 Antibody (F-4) Alexa Fluor® 546 | sc-365689 AF546 | 200 µg/ml | $364.00 | |||
AKR1B10 Antibody (F-4) Alexa Fluor® 594 | sc-365689 AF594 | 200 µg/ml | $364.00 | |||
AKR1B10 Antibody (F-4) Alexa Fluor® 647 | sc-365689 AF647 | 200 µg/ml | $364.00 | |||
AKR1B10 Antibody (F-4) Alexa Fluor® 680 | sc-365689 AF680 | 200 µg/ml | $364.00 | |||
AKR1B10 Antibody (F-4) Alexa Fluor® 790 | sc-365689 AF790 | 200 µg/ml | $364.00 |