AKAP 13 Antibody (A-3): sc-393953
- AKAP 13 Antibody (A-3) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against amino acids 1-284 mapping at the N-terminus of AKAP 13 of human origin
- recommended for detection of AKAP 13 of human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for AKAP 13 Antibody (A-3) for WB applications. These reagents are now offered in bundles with AKAP 13 Antibody (A-3) (see ordering information below).
AKAP 13 Antibody (A-3) is a mouse monoclonal IgG1 antibody that detects AKAP 13 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). AKAP 13, also known as breast cancer nuclear receptor-binding auxiliary protein, plays a crucial role in cellular signaling by acting as a scaffold for protein kinase A (PKA) and facilitating PKA localization to specific cellular compartments. This compartmentalization is vital for PKA signaling specificity, allowing PKA to interact with distinct substrates in a regulated manner, thereby influencing various cellular processes such as TLR2 signaling, NFκB activation, and actin stress fiber formation. AKAP 13 exists in seven isoforms, each localizing to different cellular regions, including the cytoplasm, nucleus, or cell membrane, depending on the isoform expressed. This dynamic localization is essential for proper AKAP 13 functioning in diverse signaling pathways, making AKAP 13 a significant player in cellular responses and potential therapeutic target in diseases such as cancer. Anti-AKAP 13 antibody (A-3) is an invaluable tool for researchers exploring AKAP 13′s intricate roles in human biology.
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AKAP 13 Antibody (A-3) References:
- AKAP13, a RhoA GTPase-specific guanine exchange factor, is a novel regulator of TLR2 signaling. | Shibolet, O., et al. 2007. J Biol Chem. 282: 35308-17. PMID: 17878165
- Genome-Wide Gene Expression Analysis Shows AKAP13-Mediated PKD1 Signaling Regulates the Transcriptional Response to Cardiac Hypertrophy. | Johnson, KR., et al. 2015. PLoS One. 10: e0132474. PMID: 26192751
- Protein Kinase A-induced tamoxifen resistance is mediated by anchoring protein AKAP13. | Bentin Toaldo, C., et al. 2015. BMC Cancer. 15: 588. PMID: 26272591
- Mice deficient in AKAP13 (BRX) develop compulsive-like behavior and increased body weight. | Maravet Baig, K., et al. 2018. Brain Res Bull. 140: 72-79. PMID: 29653158
- A-Kinase Anchoring Protein 13 (AKAP13) Augments Progesterone Signaling in Uterine Fibroid Cells. | Ng, SSM., et al. 2019. J Clin Endocrinol Metab. 104: 970-980. PMID: 30239831
- Prognostic value of AKAP13 methylation and expression in lung squamous cell carcinoma. | Wang, HL., et al. 2020. Biomark Med. 14: 503-512. PMID: 32208871
- CD47 promotes T-cell lymphoma metastasis by up-regulating AKAP13-mediated RhoA activation. | Kitai, Y., et al. 2021. Int Immunol. 33: 273-280. PMID: 33406263
- AKAP13 couples GPCR signaling to mTORC1 inhibition. | Zhang, S., et al. 2021. PLoS Genet. 17: e1009832. PMID: 34673774
- MiR-629-5p Promotes Prostate Cancer Development and Metastasis by Targeting AKAP13. | Liu, Y., et al. 2021. Front Oncol. 11: 754353. PMID: 34722307
- AKAP13 Enhances CREB1 Activation by FSH in Granulosa Cells. | Cayton Vaught, KC., et al. 2023. Reprod Sci. 30: 1528-1539. PMID: 36401072
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
AKAP 13 Antibody (A-3) | sc-393953 | 200 µg/ml | $322.00 | |||
AKAP 13 Antibody (A-3): m-IgG Fc BP-HRP Bundle | sc-538343 | 200 µg Ab; 10 µg BP | $361.00 | |||
AKAP 13 Antibody (A-3): m-IgGκ BP-HRP Bundle | sc-535936 | 200 µg Ab; 40 µg BP | $361.00 |