AK4 Antibody (G-3): sc-398661

AK4 Antibody (G-3) is a mouse monoclonal IgG1 antibody that detects adenylate kinase 4 (AK4) in mouse, rat, and human samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). AK4 is a crucial enzyme involved in the regulation of adenine nucleotide metabolism, playing a significant role in cellular energy homeostasis by facilitating the transfer of phosphate groups between adenine nucleotides like AMP, ADP, and ATP. This function is vital for maintaining the energy balance within cells, influencing various metabolic pathways, gene expression, and signaling cascades. Notably, AK4 is predominantly expressed in the central nervous system, where AK4 is synthesized as a 223 amino acid protein from the middle stage of embryogenesis through adulthood. The localization of AK4 in the central nervous system underscores AK4′s importance in neuronal function and development, as AK4 helps regulate energy supply in a highly active metabolic environment. Furthermore, inherited mutations that lead to deficiencies in adenylate kinases, including AK4, have been associated with conditions such as hemolytic anemia, highlighting the clinical relevance of this protein. Anti-AK4 antibody (G-3) is an essential tool for researchers investigating the role of adenylate kinases in cellular metabolism and related pathologies.

The preferred AK4 antibody is AK4 Antibody (A-9): sc-271161.