AIPL1 Antibody (5-RY34): sc-134253
- AIPL1 Antibody (5-RY34) is a mouse monoclonal IgG2a κ AIPL1 antibody provided at 100 µg/ml
- raised against recombinant AIPL1 protein of human origin
- recommended for detection of AIPL1 of human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for AIPL1 Antibody (5-RY34). This work is in progress.
AIPL1 Antibody (5-RY34) is a mouse monoclonal IgG2a kappa light chain antibody that detects the AIPL1 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-AIPL1 antibody (5-RY34) is available as a non-conjugated format. The aryl hydrocarbon receptor interacting protein-like 1 (AIPL1) plays a vital role in the proper folding and stabilization of proteins, which is essential for maintaining cellular function and integrity. AIPL1 is particularly important in the retina, where expression occurs in developing cone and rod photoreceptors, and remains restricted to rod photoreceptors in the adult human retina. AIPL1′s localization to the nucleus and cytoplasm allows participation in critical cellular processes, including protein trafficking, which ensures proteins reach their correct destinations within the cell. AIPL1 interacts with the cell cycle regulator protein NUB1, highlighting involvement in cellular regulation. Defects in the gene encoding AIPL1 can lead to Leber congenital amaurosis type IV, a severe inherited disorder that results in early-onset blindness, underscoring AIPL1′s significance in vision and overall eye health.
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AIPL1 Antibody (5-RY34) References:
- Role of AIP and its homologue the blindness-associated protein AIPL1 in regulating client protein nuclear translocation. | van der Spuy, J. and Cheetham, ME. 2004. Biochem Soc Trans. 32: 643-5. PMID: 15270697
- The Leber congenital amaurosis protein AIPL1 modulates the nuclear translocation of NUB1 and suppresses inclusion formation by NUB1 fragments. | van der Spuy, J. and Cheetham, ME. 2004. J Biol Chem. 279: 48038-47. PMID: 15347646
- AIPL1, the protein that is defective in Leber congenital amaurosis, is essential for the biosynthesis of retinal rod cGMP phosphodiesterase. | Liu, X., et al. 2004. Proc Natl Acad Sci U S A. 101: 13903-8. PMID: 15365173
- Leber congenital amaurosis: a genetic paradigm. | Allikmets, R. 2004. Ophthalmic Genet. 25: 67-79. PMID: 15370538
- Purification, characterisation and intracellular localisation of aryl hydrocarbon interacting protein-like 1 (AIPL1) and effects of mutations associated with inherited retinal dystrophies. | Gallon, VA., et al. 2004. Biochim Biophys Acta. 1690: 141-9. PMID: 15469903
- A missense mutation in GUCY2D acts as a genetic modifier in RPE65-related Leber Congenital Amaurosis. | Silva, E., et al. 2004. Ophthalmic Genet. 25: 205-17. PMID: 15512997
- Retinal degeneration in Aipl1-deficient mice: a new genetic model of Leber congenital amaurosis. | Dyer, MA., et al. 2004. Brain Res Mol Brain Res. 132: 208-20. PMID: 15582159
- Clinical phenotypes in carriers of Leber congenital amaurosis mutations. | Galvin, JA., et al. 2005. Ophthalmology. 112: 349-56. PMID: 15691574
- [Leber congenital amaurosis: comprehensive survey of genetic heterogeneity. A clinical definition update]. | Hanein, S., et al. 2005. J Fr Ophtalmol. 28: 98-105. PMID: 15767905
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
AIPL1 Antibody (5-RY34) | sc-134253 | 100 µg/ml | $339.00 |