AIM2 Antibody (3C4G11): sc-293174
- AIM2 Antibody (3C4G11) is a mouse monoclonal IgG1, cited in 12 publications, provided at 50 µg/0.5 ml
- raised against amino acids 1-195 of AIM2 of human origin
- recommended for detection of AIM2 of mouse, rat and human origin by WB, IP, IF, FCM and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for AIM2 Antibody (3C4G11). This work is in progress.
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AIM2 Antibody (3C4G11) is a mouse monoclonal IgG1 antibody that detects Interferon-inducible protein AIM2 (Absent in melanoma 2) in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). AIM2 is a 343 amino acid protein belonging to the HIN-200 family and is primarily localized in the nucleus, where AIM2 plays a crucial role in cellular responses to DNA damage and pathogen detection. AIM2 contains one DAPIN domain and one HIN-200 domain; the DAPIN domain facilitates protein-protein interactions, while the HIN-200 domain is essential for direct DNA binding. This interaction leads to the activation of Caspase-1, a key player in the inflammatory response. AIM2 functions as a tumor suppressor by repressing NFκB transcriptional activity, and AIM2 expression is notably high in tissues such as the small intestine, testis, peripheral blood leukocytes, and spleen. Defects in AIM2 have been implicated in the development of microsatellite unstable colon cancers, highlighting AIM2′s critical role in maintaining genomic stability and immune responses. Anti-AIM2 antibody (3C4G11) is an invaluable tool for researchers studying the mechanisms of cancer and inflammation, providing insights into AIM2′s function and potential as a therapeutic target.
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AIM2 Antibody (3C4G11) References:
- PKM2-dependent glycolysis promotes NLRP3 and AIM2 inflammasome activation. | Xie, M., et al. 2016. Nat Commun. 7: 13280. PMID: 27779186
- Role of AIM2 inflammasome in inflammatory diseases, cancer and infection. | Sharma, BR., et al. 2019. Eur J Immunol. 49: 1998-2011. PMID: 31372985
- AIM2 in regulatory T cells restrains autoimmune diseases. | Chou, WC., et al. 2021. Nature. 591: 300-305. PMID: 33505023
- The AIM2 inflammasome exacerbates atherosclerosis in clonal haematopoiesis. | Fidler, TP., et al. 2021. Nature. 592: 296-301. PMID: 33731931
- AIM2-driven inflammasome activation in heart failure. | Onódi, Z., et al. 2021. Cardiovasc Res. 117: 2639-2651. PMID: 34117866
- AIM2 deficiency in B cells ameliorates systemic lupus erythematosus by regulating Blimp-1-Bcl-6 axis-mediated B-cell differentiation. | Yang, M., et al. 2021. Signal Transduct Target Ther. 6: 341. PMID: 34521812
- Overexpression of NAG-1/GDF15 prevents hepatic steatosis through inhibiting oxidative stress-mediated dsDNA release and AIM2 inflammasome activation. | Wang, Y., et al. 2022. Redox Biol. 52: 102322. PMID: 35504134
- dsDNA-induced AIM2 pyroptosis halts aberrant inflammation during rhabdomyolysis-induced acute kidney injury. | Baatarjav, C., et al. 2022. Cell Death Differ. 29: 2487-2502. PMID: 35739254
- The AIM2 inflammasome: A novel biomarker and target in cardiovascular disease. | Du, L., et al. 2022. Pharmacol Res. 186: 106533. PMID: 36332811
- Integrated NLRP3, AIM2, NLRC4, Pyrin inflammasome activation and assembly drive PANoptosis. | Oh, S., et al. 2023. Cell Mol Immunol. 20: 1513-1526. PMID: 38008850
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
AIM2 Antibody (3C4G11) | sc-293174 | 50 µg/0.5 ml | $316.00 |